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Disalcid

( salsalate )

 

500 mg round, aqua, scored, film-coated tablet

500 aqua and white capsule

750 capsule-shaped, aqua, scored, film-coated tablet

 

Purpose

To relieve pain; to reduce inflammation.

 

Indications

For mild pain relief of osteoarthritis and in local conditions. As an anti-inflammatory agent for synovitis or attachment arthritis, as in rheumatoid arthritis and ankylosing apondylitis.

 

Dosage

For pain, one or two 750 mg capsule-shaped aqua tablets every twelve hours. each 750 mg Disalcid tablet is equivalent in salicylate content to about two and a half normal-sized aspirin tablets.

 

Occasionally, higher doses may be needed. For pain, the maximum effect is reached in two hours; one to six weeks are required for anti-inflammatory action to take full effect.

 

Side effects

Common side effects include nausea, vomiting, ringing in the ears, and decreased hearing. each of these is reversible within a few hours if the drug dosage is decreased. Allergic reactions are rare but potentially include development of nasal polyps and wheezing. With an overdose of any salicylate there can be very heavy and rapid breathing, and even unconsciousness and coma.

 

Disalcid is being used more frequently in arthritis because it appears to be less toxic to the stomach than aspirin and the other NSAIDs, although definitive data are not yet available. additionally, Disalcid has less effect upon the platelets, so there is less chance of minor bleeding problems. The blood salicylate level rises more slowly and lasts longer than with aspirin; therefore, the drug does not have to be taken as often as aspirin.

 

Disalcid should be avoided during chicken pox or influenza because of the possibility of Reye's syndrome, as mentioned in the aspirin discussion.

 

Some physicians do not believe that the anti-inflammatory activity of Disalcid is as good as that of aspirin. Other physicians believe that the effects are identical. So it seems likely that Disalcid is less toxic than ordinary aspirin, but it is not clear that it is as effective a drug. It finds particular use in patients who have had problems with stomach upset from ordinary aspirin or who are in high-risk groups for gastrointestinal bleeding episodes.

 

Special hints

If you note ringing in the ears or a decrease in your hearing, decrease the dose of Disalcid; it is just a little bit too high for best results. Keep track of your Disalcid intake and always tell the doctor exactly how much you are taking.

         
         

     

         

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