( salsalate )
500 mg round, aqua, scored,
500 aqua and white capsule
750 capsule-shaped, aqua, scored,
To relieve pain; to reduce
For mild pain relief of
osteoarthritis and in local conditions. As an anti-inflammatory agent for
synovitis or attachment arthritis, as in rheumatoid arthritis and ankylosing
For pain, one or two 750 mg
capsule-shaped aqua tablets every twelve hours. each 750 mg Disalcid tablet
is equivalent in salicylate content to about two and a half normal-sized
Occasionally, higher doses may be
needed. For pain, the maximum effect is reached in two hours; one to six
weeks are required for anti-inflammatory action to take full effect.
Common side effects include
nausea, vomiting, ringing in the ears, and decreased hearing. each of these
is reversible within a few hours if the drug dosage is decreased. Allergic
reactions are rare but potentially include development of nasal polyps and
wheezing. With an overdose of any salicylate there can be very heavy and
rapid breathing, and even unconsciousness and coma.
Disalcid is being used more
frequently in arthritis because it appears to be less toxic to the stomach
than aspirin and the other NSAIDs, although definitive data are not yet
available. additionally, Disalcid has less effect upon the platelets, so
there is less chance of minor bleeding problems. The blood salicylate level
rises more slowly and lasts longer than with aspirin; therefore, the drug
does not have to be taken as often as aspirin.
Disalcid should be avoided during
chicken pox or influenza because of the possibility of Reye's syndrome, as
mentioned in the aspirin discussion.
Some physicians do not believe
that the anti-inflammatory activity of Disalcid is as good as that of
aspirin. Other physicians believe that the effects are identical. So it
seems likely that Disalcid is less toxic than ordinary aspirin, but it is
not clear that it is as effective a drug. It finds particular use in
patients who have had problems with stomach upset from ordinary aspirin or
who are in high-risk groups for gastrointestinal bleeding episodes.
If you note ringing in the ears
or a decrease in your hearing, decrease the dose of Disalcid; it is just a
little bit too high for best results. Keep track of your Disalcid intake and
always tell the doctor exactly how much you are taking.