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Trilisate

( choline magnesium trisalicylate )

 

500 mg scored, pale pink, capsule-shaped tablet

750 mg scored, white, film-coated, capsule-shaped tablet

1,000 mg scored, red, film-coated, capsule-shaped tablet

 

Purpose

To relieve pain; to reduce inflammation.

 

Indications

For mild pain relief of cartilage degeneration and local conditions. As an anti-inflammatory agent for synovitis or attachment arthritis.

 

Dosage

For pain, one or two 500 mg

tablets every twelve hours. For anti-inflammatory activity, two to three tablets every twelve hours. each 750 mg capsule Trilisate is equivalent in salicylate content to 650 mg of aspirin (two usual-sized aspirin tablets).

 

Occasionally, higher doses may be needed. The maximum effect is reached is reached in two hours for pain effects; one to six weeks are required for anti-inflammatory action to take full effect.

 

Side effects

Common side effects include nausea, vomiting, ringing in the ears, and decreased hearing. Each of these is reversible within a few hours if the drug dosage is decreased. Allergic reactions are rare but potentially include development of nasal polyps and wheezing. With an overdose of any salicylate there can be very heavy and rapid breathing, and even unconsciousness and coma.

 

Trilisate has been urged as a drug of choice in arthritis because it is much less toxic to the stomach than aspirin. Additionally, there is less effect upon the platelets, so there is less chance o a bleeding problem. The blood salicylate level rises more slowly and lasts longer; hence, the drug does not have to be taken as often as aspirin.

 

But a controversy has arisen because some physicians do not believe that the anti-inflammatory activity of Trilisate is nearly as good as that of aspirin. Other physicians believe that the effects are identical. So, it seems clear that Trilisate is less toxic than ordinary aspirin, but is is not clear that it is as effect as a drug. It finds particular use in patients who have had problems with stomach upset from ordinary aspirin. Trilisate does require a prescription; it is not clear why a prescription should be required for this drug any more than for regular aspirin.

 

Special hints

If you note ringing in the ears or a decrease in your hearing, decrease the dose of Trilisate; it is just a little bit too high for best results. Keep track of your Trilisate intake and always tell the doctor exactly how much you are taking. It is possible that there may be drug interference between Trilisate and the nonsteroidal anti-inflammatory agents, so you will usually not want to take them at the same time.

         
         

     

         

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