( sulindac )
150 mg, 200 mg bright yellow,
To reduce inflammation; to
For anti-inflammatory action and
One 150 mg tablet twice a day.
This drug also comes in a 200 mg tablet, and dosage may be increased to 200
mg twice a day if needed. Maximum recommended dose is 400 mg a day.
Gastrointestinal side effects,
with irritation of the stomach lining, are the most common, and include
nausea, indigestion, and heartburn. Stomach pain has been reported in 10% of
subjects, and nausea, diarrhea, constipation, headache, and rash in from 3%
to 9%. Ringing in the ears, fluid retention, itching, and nervousness have
been reported. Allergic reactions are rare. The use of aspirin in
combination with this drug is not recommended by the manufacturer, since
aspirin apparently decreases absorption from the intestine. Hospitalization
for gastrointestinal bleeding occurs in about 1% of those taking full doses
for one year.
Sulindac has no particular
advantages or disadvantages over the other anti-inflammatory agents, except
that it may cause the minor kidney side effects less frequently and
therefore is sometimes used for people with heart or kidney problems.
For stomach upset, take the pills
after meals; skip a dose or two if necessary. Antacids may be used for
gastrointestinal problems and may sometimes help. Check with your doctor if
the distress continues. Maximum therapeutic effect is achieved after about
six weeks of treatment, but you should be able to see a major effect in the
first week if Clinoril is going to be a really good drug for you.