( indomethacin )
25 mg, 50 mg blue and white
75 mg sustained-release, blue /
50 mg blue suppository
To reduce inflammation; to slight reduce pain.
For reduction of inflammation and
for mild pain relief
One 25 mg capsule three to four
times daily. For men or large women, doses totaling as high as 150 to 200 mg
( six to eight capsules ) may be required and tolerated each day. Indocin is
also available in 50 mg capsules and in a 75 mg sustained-release form which
needs to be taken only twice daily.
Irritation of the stomach lining,
including nausea, indigestion, and heartburn, occurs with a number of
people. Allergic reactions (including skin rash and asthma) are very rare. A
substantial problem, not present with other drugs of this class, is headache
and a bit of a goofy feeling. Hospitalization for gastrointestinal bleeding
is seen in 1% to 2% of those on full doses for one year.
Many doctors find Indocin to be
rather weak for treatment of rheumatoid arthritis in early stages, although
it is sometimes effective in later stages. in a long-term illness, maximum
effect may take six weeks or so, but you should be able to tell within one
week if it is going to be a major help. this is the cheapest of the new
nonsteroidal drugs, so if it works you may save money. On the other hand, it
may be one of the most toxic drugs. Some studies suggest that Indocin
actually increases the rate of cartilage destruction in osteoarthritis of
There are also some problems with absorption of Indocin from the intestine.
If you take it after meals, you have less stomach irritation, but some
people do not absorb the drug very well. So, for maximum effect you need to
take it on an empty stomach and for maximum comfort on a full stomach. trial
and error may be necessary to establish the best regimen for you. Aspirin
poses another problem. when some individuals take aspirin with Indocin, the
Indocin is not absorbed from the intestine. Usually you will not want tot
take these two drugs together, since you will get more irritation of the
stomach lining but no more therapeutic effect than if you just took the
aspirin. If this drug makes you feel mentally or emotionally fuzzy for more
than the firs few weeks, we think that is a good reason to discuss a change
in medication with your doctor.