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Indocin

( indomethacin )

 

25 mg, 50 mg blue and white capsule

75 mg sustained-release, blue / white capsule

50 mg blue suppository

 

Purpose

To reduce inflammation; to slight reduce pain.

 

Indications

For reduction of inflammation and for mild pain relief

 

Dosage

One 25 mg capsule three to four times daily. For men or large women, doses totaling as high as 150 to 200 mg ( six to eight capsules ) may be required and tolerated each day. Indocin is also available in 50 mg capsules and in a 75 mg sustained-release form which needs to be taken only twice daily.

 

Side effects

Irritation of the stomach lining, including nausea, indigestion, and heartburn, occurs with a number of people. Allergic reactions (including skin rash and asthma) are very rare. A substantial problem, not present with other drugs of this class, is headache and a bit of a goofy feeling. Hospitalization for gastrointestinal bleeding is seen in 1% to 2% of those on full doses for one year.

 

Special hints

Many doctors find Indocin to be rather weak for treatment of rheumatoid arthritis in early stages, although it is sometimes effective in later stages. in a long-term illness, maximum effect may take six weeks or so, but you should be able to tell within one week if it is going to be a major help. this is the cheapest of the new nonsteroidal drugs, so if it works you may save money. On the other hand, it may be one of the most toxic drugs. Some studies suggest that Indocin actually increases the rate of cartilage destruction in osteoarthritis of the hip.

 

There are also some problems with absorption of Indocin from the intestine. If you take it after meals, you have less stomach irritation, but some people do not absorb the drug very well. So, for maximum effect you need to take it on an empty stomach and for maximum comfort on a full stomach. trial and error may be necessary to establish the best regimen for you. Aspirin poses another problem. when some individuals take aspirin with Indocin, the Indocin is not absorbed from the intestine. Usually you will not want tot take these two drugs together, since you will get more irritation of the stomach lining but no more therapeutic effect than if you just took the aspirin. If this drug makes you feel mentally or emotionally fuzzy for more than the firs few weeks, we think that is a good reason to discuss a change in medication with your doctor.

         
         

     

         

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