( meclofenamate )
50 mg dark yellow / light yellow
100 mg dark yellow / off-white
To reduce inflammation; to reduce pain.
For anti-inflammatory action in
attachment arthritis, synovitis, local conditions, and occasionally
degenerative cartilage changes.
The total daily dosage is 200 to
400 mg, usually given in three or four equal doses.
This is probably the most toxic
NSAID. Gastrointestinal side effects are most commonly reported and include
diarrhea in approximately one-quarter of patients, nausea in 11%, and other
gastrointestinal problems in 10%. Over the long term, at least one-third of
patients will have at least one episode of diarrhea. With this drug the
diarrhea is more severe than with any of the other drugs of this class, and
sufficiently so to require discontinuation of treatment in approximately 4%
of patients. A variety of other generally minor side effects have been
reported but do not appear to be at all common. Hospitalization for
gastrointestinal bleeding is seen in 1% to 2% of those on full doses for one
This drug was introduced in 1980,
and has been used relatively little. It is probably comparable in
effectiveness to the other nonsteroidal agents. It is not yet recommended
for children, and its effects have not been studied in patients with very
sever rheumatoid arthritis. It may be taken with meals or milk to control
gastrointestinal complaints. Maximum effect is achieved after about six
weeks of treatment, but you should be able to see a major effect n the first
week if it is going to be a really good drug for you. Avoidance of aspirin
and other medications while taking this drug is advisable but not essential.