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Meclomen

( meclofenamate )

 

50 mg dark yellow / light yellow capsule

100 mg dark yellow / off-white capsule

 

Purpose

To reduce inflammation; to reduce pain.

 

Indications

For anti-inflammatory action in attachment arthritis, synovitis, local conditions, and occasionally degenerative cartilage changes.

 

Dosage

The total daily dosage is 200 to 400 mg, usually given in three or four equal doses.

 

Side effects

This is probably the most toxic NSAID. Gastrointestinal side effects are most commonly reported and include diarrhea in approximately one-quarter of patients, nausea in 11%, and other gastrointestinal problems in 10%. Over the long term, at least one-third of patients will have at least one episode of diarrhea. With this drug the diarrhea is more severe than with any of the other drugs of this class, and sufficiently so to require discontinuation of treatment in approximately 4% of patients. A variety of other generally minor side effects have been reported but do not appear to be at all common. Hospitalization for gastrointestinal bleeding is seen in 1% to 2% of those on full doses for one year.

 

Special hints

This drug was introduced in 1980, and has been used relatively little. It is probably comparable in effectiveness to the other nonsteroidal agents. It is not yet recommended for children, and its effects have not been studied in patients with very sever rheumatoid arthritis. It may be taken with meals or milk to control gastrointestinal complaints. Maximum effect is achieved after about six weeks of treatment, but you should be able to see a major effect n the first week if it is going to be a really good drug for you. Avoidance of aspirin and other medications while taking this drug is advisable but not essential.

         
         

     

         

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