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Sandimmune

( cyclosporine )

 

25 mg capsule

100 mg capsule


Purpose

To reduce inflammation and disease progression in rheumatoid arthritis.

 

Indications

For reduction of inflammation in difficult severe rheumatoid arthritis not responsive to other agents. ( This use is not approved by the Food and Drug Administration )


Dosage

Use in rheumatoid arthritis is generally 3 to 5 mg per kilogram body weight per day. For a 150-pound man this is 200 to 350 mg per day.


Side effects

The principal adverse reactions are kidney failure, tremor, excess hair growth, and problems with the gums. In rheumatoid arthritis the major problem has been with the kidneys and this often requires discontinuation of the drug. the kidney failure is generally reversible.

 

Special hints

Cyclosporine was developed as a drug to prevent rejection of kidney, heart, and other organ transplants. It is a strong immunosuppressant. in rheumatoid arthritis its use is reserved for severely affected persons and it should be given only by physicians who are thoroughly familiar with its use. It can be very effective in some patients. The problem is rheumatoid arthritis patients is the kidney damage and this occurs at lower doses than in transplant patients. Hence, the dose is lower for rheumatoid arthritis patients. Some patients have had severe disease flare-ups after stopping cyclosporine. Researchers are exploring several ways to reduce the kidney problems, and we may have some progress in this area soon.

         
         

     

         

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