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Adalat/Adalat
Retard
Contents:
Nifedipine.
Indications:
Chronic stable angina pectoris,
vasospastic angina, unstable angina, ( not registered for Adalat-5),
post-infarct angina. Hypertension (not registered for Adalat-5).
Dosage:
Cap
5-10 mg three times daily. Can
increase stepwise to 20 mg three times daily.
Coronary spasms
Temporarily 20 mg 4-6 times
daily. If rapid onset required, 10-20 mg bite through & swallow. Dosage
interval for 20 mg : never < 2 hr.
Retard tab
1 tab twice daily; in some cases
2 tab twice daily. Dosage interval between tabs never < 4 hr.
Contraindications:
Cardiovascular shock; pregnancy &
lactation.
Special Precautions:
Severe hypotension; close
monitoring of dialysis patients with malignant hypertension; heart failure,
severe aortic stenosis.
Adverse Reactions:
Initially mild & transient
vasodilatation, hypotensive,
Rarely
Gastrointestinal, skin & other
reactions.
Very rarely
chest pain (if relationship
established, discontinue therapy).
Extremely rarely
on prolonged use gingival
hyperplasia, gynaecomastia (both regressing on discontinuation); temporary
hyperglycaemia, liver function disturbances (including intrahepatic
cholestasis). Ability to drive or operate machinery may be impaired.
Drug interactions:
Effect enhanced by
antihypertensive agents, cimetidine & β-receptor blockers. Digoxin,
quinidine (monitor plasma level).
Presentation/Packing:
Cap 5 mg x 50's. 10 mg x
30's.
Retard tab 20 mg x 30's |
