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Adalat/Adalat Retard

 

Contents:

Nifedipine.

 

Indications:

Chronic stable angina pectoris, vasospastic angina, unstable angina, ( not registered for Adalat-5), post-infarct angina. Hypertension (not registered for Adalat-5).

 

Dosage:

Cap

5-10 mg three times daily. Can increase stepwise to 20 mg three times daily.

 

Coronary spasms

Temporarily 20 mg 4-6 times daily. If rapid onset required, 10-20 mg bite through & swallow. Dosage interval for 20 mg : never < 2 hr.

 

Retard tab

1 tab twice daily; in some cases 2 tab twice daily. Dosage interval between tabs never < 4 hr.

 

Contraindications:

Cardiovascular shock; pregnancy & lactation.

 

Special Precautions:

Severe hypotension; close monitoring of dialysis patients with malignant hypertension; heart failure, severe aortic stenosis.

 

Adverse Reactions:

Initially mild & transient vasodilatation, hypotensive,

Rarely

Gastrointestinal, skin & other reactions.

Very rarely

chest pain (if relationship established, discontinue therapy).

Extremely rarely

on prolonged use gingival hyperplasia, gynaecomastia (both regressing on discontinuation); temporary hyperglycaemia, liver function disturbances (including intrahepatic cholestasis). Ability to drive or operate machinery may be impaired.

 

Drug interactions:

Effect enhanced by antihypertensive agents, cimetidine & β-receptor blockers. Digoxin, quinidine (monitor plasma level).

 

Presentation/Packing:

Cap 5 mg x 50's. 10 mg x 30's.

Retard tab 20 mg x 30's

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