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Aminophylline DBL

 

Contents:

Aminophylline.

 

Indications:

Asthma, bronchopneumonia, bronchitis, Cheyne-Stokes respiratory, paroxysmal dyspnoea associated with left heart failure.

 

Dosage:

Adult

Loading dose: 6 mg/kg. Maintenance: 0.5 mg/kg/hr IV infusion.

 

Cardiac failure 0.3 mg/kg/hr.

Liver disease 0.2 mg/mg/hr.

Both cardiac failure & liver disease 0.1 mg/kg/hr.

 

Children

5 mg/kg/6hourly slow IV injection.

 

Contraindications:

Allergy to theophyllines, caffeine, theobromine, hypersensitivity to ethylenediamine. Peptic ulcer, active gastritis; severe renal or liver impairment.

 

Special Precautions:

Hyperthyroidism; glaucoma, diabetes mellitus, angina pectoris. Pulmonary, CV, renal or hepatic diseases. Pregnancy; children & elderly.

 

Adverse Reactions:

Gastrointestinal upset, nervousness, urinary frequency.

 

Drug interactions:

Mutual antagonism with β-adrenergic blockers. May increase CNS stimulation caused by sympathomimetics & decrease effectiveness of lithium & phenytoin. May enhance toxicity of digitalis glycosides..

 

Presentation/Packing:

Ampoules 25 mg/mL x 10 mL x 50's

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