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Amoxitab / Amoxicap

Description
Amoxitab 125 Tablet (Flavoured) - Round, pink uncoated tablet with tuttifrutti flavour, "HOVID" embossed on one face and breakbar embossed on the other face.
Amoxitab 250 Tablet (Flavoured) - Round, light yellow uncoated tablet with grenadine flavour, "HOVID" embossed on one face and break-bar embossed on the other face.
Amoxicap 250 Capsule - Scarlet and grey capsule with "AX250" printed on one end and "HD" printed on the other end.
Amoxicap 500 Capsule - Scarlet opaque/yellow opaque capsule with "AX500" printed on one end and "HD" printed on the other end.

Composition
Amoxitab 125 Tablet (Flavoured) - Amoxycillin (as trihydrate) 125 mg/tablet

Amoxitab 250 Tablet (Flavoured) - Amoxycillin (as trihydrate) 250 mg/tablet

Amoxicap 250 Capsule - Amoxycillin (as trihydrate) 250 mg/capsule

Amoxicap 500 Capsule - Amoxycillin (as trihydrate) 500 mg/capsule

Actions and Pharmacology
Amoxycillin, a bactericidal antibiotic, inhibits bacterial cell wall synthesis by preventing cross-linkage of peptidoglycan chains which is necessary for bacterial cell wall strength and rigidity. Cell division and growth are inhibited and lysis of susceptible bacteria frequently occurs. Oral absorption is not greatly influenced by the presence of food and excretion is mainly via renal and biliary systems.

Indications
For treatment of :
Ear, nose and throat infections caused by streptococci, pneumococci, nonpenicillinase - producing staphylococci and H. influenzae.

Genitourinary tract infections caused by E. coli, P mirabilis, S. faecalis.

Skin and soft-tissues infections caused by streptococci, nonpenicillinase - producing staphylococci and E. coli.

Anogenital and urethral gonorrhoea caused by N. gonorrhoea.

Contraindications
Contraindicated in patients known to be sensitive to penicillin.
Avoid in patients with infectious mononucleosis because of increased risk of skin rashes.

Precautions
As with any potent drug, periodic assessment of renal, hepatic and hematopoietic function should be made during prolonged therapy. The possibility of superinfections with myocotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur (usually involving Enterobacter, Pseudomonas or Candida), the drug should be discontinued and/or appropriate therapy instituted.
Caution in patients with known histories of allergy.

Should be used with caution in pregnancy and lactation. Safety for use in pregnancy has not been established.

Reduced doses may be required in patients with severe impaired renal function.

Warnings
Serious and occasionally fatal hypersensitivity (anaphylactoid) reactions have been reported in patients on penicillin therapy although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillins. These reactions are more likely to occur in individuals with a history of sensitivity to multiple allergens. There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe reactions when treated with Cephalosporins. Before therapy with any penicillin, careful inquiry should be made concerning previous hypersensitivity reactions to Penicillins, Cephalosporins or other allergens. If an allergic reaction occurs, appropriate therapy should be instituted and discontinuance of amoxicillin therapy considered. Serious anaphylactoid reactions require immediate emergency treatment with Epinephrine. Oxygen, intravenous steroids and airway management, including incubation, should also be administered as indicated.

Side/Adverse Effects
Hypersensitivity reaction : Rash and less frequently as exfoliative dermatitis or erythema multiforme.

Hemolytic effects : Hemolytic anemia / anemia / eosinophilia / leukopenia / neutropenia / agranulocytosis / thrombocytopenia / thrombocytopenic purpura.

G. I. effects : Diarrhoea, nausea, vomiting, black hairy tongue, glossitis, stomatitis, sore mouth or tongue.

Renal effects : Acute interstitial nephritis.

Hepatic effects : A moderate increase in serum concentration of AST (SGOT).

Drug Interactions
Concurrent use with Allopurinol or Probenecid requires careful monitoring.
Concurrent use with Chloramphenicol, Erythromycins, Sulfonamides and Tetracycline may interfere with the bactericidal effect of amoxycillin.

Overdose
Clinical features : Anorexia, nausea, vomiting, abdominal discomfort, diarrhoea.

Treat overdose by emesis or gastric lavage, if appropriate and other supportive measures.

Dosage and Administration
Adults : Oral, 250 to 500 mg every eight hours; or as directed.
Children :

Infants up to 6 kg of body weight - Oral, 25 - 50 mg every 8 hours
Infants 6 - 8 kg of body weight - Oral, 50 - 100 mg every 8 hours
Infants and children 8 - 20 kg of body weight - Oral, 6.7 - 13.3 mg/kg of body weight every 8 hours

Children 20 kg of body weight and over - See adult dose

Note : The information given here is limited. For further information consult your doctor or pharmacist.

 

Storage

Store below 25C. Protect from moisture.

 

Presentation/Packing

Tablet 125 mg x 100's, 1000's, blisters 10 x 10's
Tablet 250 mg x 100's, 500's, blisters 10 x 10's
Capsule 250 mg x 100's, 500's, 1000's, blisters 10 x 10's

Capsule 500 mg x 100's, 500's, blisters 10 x 10's

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