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ARAMINE

 

Contents:

Metaraminol bitartrate.

 

Indications:

Prevention & treatment of the acute hypotensive state occurring with spinal anesthesia & as adjunctive treatment of hypotension.

 

Dosage:

IM or SC injection

Prevention of hypotension 2-10 mg.

IV infusion

Adjunctive treatment of hypotension 15-100 mg in 500 mL of sodium CI injection or 5% dextrose injection. Max: 500/500 mL of infusion fluid.

Direct IV injection

In severe shock 0.5-5 mg, followed by an infusion of 15-100 mg in 500 mL of diluent. Titrate to blood pressure response. Prolonged action of this drug may prevent adequate expansion of circulating volume & cause perpetuation of shock.

 

Contraindication:

Usage with cyclopropane or halothane anesthesia

 

Special Precautions:

Avoid excessive blood pressure response. Patients with cirrhosis, heart or thyroid disease, hypertension, diabetes or history of malaria. Digitalized patients. With the prolonged action of this drug, a cumulative effect is possible which may produce a prolonged elevation of blood pressure. Prolonged action of this drug may prevent adequate expansion of circulating volume & cause perpetuation of shock. Effects during pregnancy, in nursing mothers or in children have not been established.

 

Adverse Reactions:

May cause acute pulmonary edema, cardiac arrhythmias & arrest due to rapidly induced hypertensive responses. May cause sinus or ventricular tachycardia or other arrhythmias, especially in patients with myocardial infarction.

 

Drug Interactions:

MAO inhibitors may potentiate the action of sympathomimetics.

 

Presentation/Packing:

Vial 10 mg/mL x 10 mL.

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