Artril Forte: Each capsule contains crystalline glucosamine sulphate sodium
628 mg equivalent to glucosamine sulphate 500 mg (derived from sea food)
Artril 250: Each capsule contains crystalline glucosamine sulphate sodium
314 mg equivalent to glucosamine sulphate 250 mg (derived from sea food)
Pharmacology and pharmacodynamic
Glucosamine sulphate stimulates the anabolic metabolism of
osteo-cartilagineous issues by stimulating the biosynthesis of the mucopolysaccharides (which are the essential components of the cartilage
ground substance). Glucosamine sulphate provides lubricant activity for the
synovial fluid, it improves the synovial fluid viscosity and increase the
synovial fluid production.
Therefore Glucosamine sulphate
provides the therapeutic effects such as
• reduces articular pain
• improves the articular function
• inhibits the articular degenerative process
As adjunctive therapy in
Capsule best taken before meal.
Light or moderate osteoarthritis symptoms
One capsule Artril Forte OR two capsules Artril 250 taken twice daily for at
least 6 weeks or according to medical prescription.
Severe osteoarthritis symptoms
Initially treatment of 1 capsule
Artril Forte OR 2 capsules Artril 250, three times daily is recommended
during a period of at least 8 weeks.
Maintenance therapy should be
followed for 3 - 4 months (as according to medical prescription) by
administration of 1 capsule Artril Forte OR 2 capsules Artril 250 taken
twice daily. The treatment of osteoarthritis should be repeated every other
6 months or less according to medical prescription.
Gastrointestinal irritation such as gastro discomfort, nausea and vomiting
are rarely reported
Cardiovascular: Peripheral oedema, tachycardia were reported in few patients
following larger clinical trials investigating oral administration in
osteoarthritis. Causal relationship has not been established.
Central nervous system: Drowsiness, headache, insomnia have been observed
rarely during therapy (less than 1%).
Gastrointestinal : Nausea,
vomiting, diarrhea, dyspepsia or epigastric pain, constipation, heartburn
and anorexia have been described rarely during oral therapy with glucosamine.
Skin: skin reactions such as erythema and pruritus have been reported with
therapeutic administration of glucosamine.
This product is an adjuvant therapy and the therapeutic effect can only be
seen after 1 week. Therefore, in case of intense pains it is advisable to
take an inflammatory drug in addition during the first days of treatment.
Glucosamine may increase insulin resistance. Those with type 2 diabetes and
those who are overweight and have problems with glucose tolerance should
have their blood sugars carefully monitored if they consume glucosamine.
Glucosamine may increase insulin resistance and consequently affect glucose
Diabetics who are under medical treatment, decide to use glucosamine will
need to monitor their blood glucose and may need to adjust the doses of the
medications they take to control blood glucose. This needs to be done under
Patients who are hypersensitive
to the active ingredient.
Use in pregnancy and lactation
In pregnancy and lactation, as for other drugs, ARTRIL should be given under
Symptoms of overdosage and treatment
Artril Forte: Amber glass bottle contains 60 capsules, 14 capsules
Artril 250: Amber glass bottle
contains 100 capsules, 28 capsules
Artril Forte: Hard gelatine bovine capsule, snap-fit red/white opaque
capsule with embossed ART 500.
Artril 250: Hard gelatine bovine
capsule, snap-fit red/white opaque capsule with embossed ART 250.
Store at room temperature below
3 years from the date of