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B-Complex

 

COMPOSITION

Each tablet contains

Vitamin B1 ..... 10mg

Vitamin B2 ..... 3mg

Vitamin B6 .....1mg

Cyanocobalamin ..... 5mcg

Calcium Pantothenate ..... 1mg

Nicotinamide ..... 25mg

 

PRESENTATION
Yellow, biconvex, round tablets, 8mm in diameter with a single score - line on one side and marked Kotra logo on the other side.


INDICATION
For prevention and treatment of Vitamin B complex deficiency.


PHARMACOLOGY
Mechanism of Action:
Axcel B-Complex Tablet comprises a group of water-soluble factors closely associated in their natural occurrence. They form coenzymes essential for the metabolism of the proteins, carbohydrates or fatty acid. Vitamin B1 is particularly concerned with the carbohydrates metabolism. The vitamin is essential for the nutrition of the nerve cells, probably by promoting the oxidation of glucose within the CNS.


Vitamin B2 is converted to two coenzyme, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FDA) which are concerned with metabolism of a variety of respiratory proteins.


Vitamin B6 is converted to pyridoxal phosphate, a coenzyme for a variety of metabolic transformation of amino acids. Vitamin B6 also involved in fat metabolism.

 

Vitamin B12 is concerned in the maintenance of sulfhydryl groups in the reduced form necessary for the function of many SH-activated enzymes system. Vitamin B12 may possibly influence fat metabolism by facilitating the reduction of s-s form of coenzyme A to the active SH form. Vitamin B12 is also involved in the formation and metabolism of purines and pyrimidines, in the synthesis of nucleoproteins, and thus in the maintenance of normal haemopoiesis.

 

Calcium D - pantothenate is the calcium salt of (+) - pantothenic acid. It is converted into coenzyme A, which is concerned in a variety of enzyme-catalyzed metabolic reactions involving transfer of a cetyl (two-carbon) groups.


Nicotinamide is converted into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) which are involved in metabolism of a variety of proteins involved in tissues respiration.

 

Pharmacokinetics:
Vitamin B1 is absorbed from the gastrointestinal tract and is widely distributed to most body tissues. It is not stored to any appreciable extent in the body and amounts in excess of the body's requirement are excreted in the urine as un-changed thiamine or as its metabolite, pyrimidine.

 

Vitamin B2 is readily absorbed from the gastrointestinal tract, and in the circulation is bound to plasma proteins. It is distributed in all tissues, but little is stored in organs such as the liver and kidneys. Amounts in excess of the body's requirements are excreted unchanged in the urine.

 

Vitamin B6 is readily absorbed from the gastrointestinal tract and is converted to the active form pyridoxal phosphate. It is excreted in the urine as 4-pyridoxic acid.

 

Vitamin B12 is absorbed from the gastrointestinal tract and is bound to plasma proteins, and is stored in the liver. It is excreted in the bile and undergoes some enterohepatic re-cycling. It diffuses across the placenta. Calcium Pantothenate is readily absorbed from the gastrointestinal tract, and is present in all tissues. About 70% of the unchanged vitamin is excreted in the urine and about 30% in the feces.


Nicotinamide is readily absorbed from all portions of the intestinal tract, and is distributed in all tissues. It is excreted in the urine as unchanged nicotinamide (small amount) and as its methylated metabolites.


DOSAGE AND ADMINISTRATION
For oral administration.
Prophylactic dose is 1 tablet daily. The therapeutic dosage is 2-3 times larger or as directed by a physician.

CONTRAINDICATION
None.


SIDE EFFECTS
The vitamin B complex are essentially free from side-effects when administered orally.


STORAGE
Keep container well closed. Store below 30C. Protect from light.


PACK QUANTITIES
Available in blister pack of 10 x 10's.

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