Each tablet contains
Vitamin B1 ..... 10mg
Vitamin B2 ..... 3mg
Vitamin B6 .....1mg
Cyanocobalamin ..... 5mcg
Calcium Pantothenate ..... 1mg
Nicotinamide ..... 25mg
Yellow, biconvex, round tablets, 8mm in diameter with a single score - line on
one side and marked Kotra logo on the other side.
For prevention and treatment of Vitamin B complex deficiency.
Mechanism of Action:
Axcel B-Complex Tablet comprises a group of water-soluble factors closely
associated in their natural occurrence. They form coenzymes essential for the
metabolism of the proteins, carbohydrates or fatty acid. Vitamin B1 is
particularly concerned with the carbohydrates metabolism. The vitamin is
essential for the nutrition of the nerve cells, probably by promoting the
oxidation of glucose within the CNS.
Vitamin B2 is converted to two coenzyme, flavin mononucleotide (FMN) and flavin
adenine dinucleotide (FDA) which are concerned with metabolism of a variety of
Vitamin B6 is converted to pyridoxal phosphate, a coenzyme for a variety of
metabolic transformation of amino acids. Vitamin B6 also involved in fat
Vitamin B12 is concerned in the maintenance of sulfhydryl groups in the reduced
form necessary for the function of many SH-activated enzymes system. Vitamin B12
may possibly influence fat metabolism by facilitating the reduction of s-s form
of coenzyme A to the active SH form. Vitamin B12 is also involved in the
formation and metabolism of purines and pyrimidines, in the synthesis of
nucleoproteins, and thus in the maintenance of normal haemopoiesis.
Calcium D - pantothenate is the calcium salt of (+) - pantothenic acid. It is
converted into coenzyme A, which is concerned in a variety of enzyme-catalyzed
metabolic reactions involving transfer of a cetyl (two-carbon) groups.
Nicotinamide is converted into nicotinamide adenine dinucleotide (NAD) and
nicotinamide adenine dinucleotide phosphate (NADP) which are involved in
metabolism of a variety of proteins involved in tissues respiration.
Vitamin B1 is absorbed from the gastrointestinal tract and is widely distributed
to most body tissues. It is not stored to any appreciable extent in the body and
amounts in excess of the body's requirement are excreted in the urine as
un-changed thiamine or as its metabolite, pyrimidine.
Vitamin B2 is readily absorbed from the gastrointestinal tract, and in the
circulation is bound to plasma proteins. It is distributed in all tissues, but
little is stored in organs such as the liver and kidneys. Amounts in excess of
the body's requirements are excreted unchanged in the urine.
Vitamin B6 is readily absorbed from the gastrointestinal tract and is converted
to the active form pyridoxal phosphate. It is excreted in the urine as
Vitamin B12 is absorbed from the gastrointestinal tract and is bound to plasma
proteins, and is stored in the liver. It is excreted in the bile and undergoes
some enterohepatic re-cycling. It diffuses across the placenta. Calcium
Pantothenate is readily absorbed from the gastrointestinal tract, and is present
in all tissues. About 70% of the unchanged vitamin is excreted in the urine and
about 30% in the feces.
Nicotinamide is readily absorbed from all portions of the intestinal tract, and
is distributed in all tissues. It is excreted in the urine as unchanged
nicotinamide (small amount) and as its methylated metabolites.
DOSAGE AND ADMINISTRATION
For oral administration.
Prophylactic dose is 1 tablet daily. The therapeutic dosage is 2-3 times larger
or as directed by a physician.
The vitamin B complex are essentially free from side-effects when administered
Keep container well closed. Store below 30°C. Protect from light.
Available in blister pack of 10 x 10's.