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Became Ingredient(s)
Each tablet contains:
Carbinoxamine Maleate .......................4mg
Pseudoephedrine HCI ........................60mg
Action(s)
1. Carbinoxamine Maleate is used in the treatment of allergy. Act by
competing with histamine for H1-receptor sites on effector cells. They
thereby prevent but do not reverse response mediated by histamine alone. The
antimuscarinic actions of most antihistamine provide a drying effect on the
nasal mucosa.
2. Pseudoephedrine HCI is a decongestantsympathomimetic amines act on
alpha-adrenergic receptors in the mucosa of the respiratory tract to produce
vasoconstriction which temporarily reduces the swelling associated with
inflammation of the mucous membranes lining the nasal passages.
3. Carbinoxamine Maleate and Pseudoephedrine are well absorbed from the
gastrointestinal tract after oral administration. Pseudoephedrine is
incompletely metabolized in the liver. It has a half-life of 4.5 to 8 hours
and has an onset of action within 30 minutes. Its duration of action is 4 to
6 hours. It is primarily excreted in the urine. Carbinoxamine has a
half-life of 10 to 20 hours. Its duration of action is 3 to 6 hours with an
onset of action within 15 to 60 minutes.
Indication(s)
For the relief of seasonal and allergic rhinitis and vasomotor rhinitis
symptoms, such as sneezing, stuff nose and running nose.
Dosage and Administration
Adults: 1 tablet, given 3 to 4 times a day.
Children:
6 years and above: I tablet, given 3 to 4 times a day.
18 months to 6 years: 1/2 tablet, given 3 to 4 times a day.
Precaution(s) / Warning(s)
1. Should be used with caution in patients who may be hypersusceptible to
their effects particularly those with hyperthyroidism and great care for
patients with cardiovascular disease.
2. Care is also required when given to patients with diabetes mellitus or
closed-angle glaucoma.
3. Should not be given to premature infants or neonate. 4. Safety use
during pregnancy has not been established. 5. Should be used with caution in
nursing mothers.
Side Effect(s) / Adverse Reaction(s)
Carbinoxamine Maleate: Sedation, dizziness, diplopia, vomiting, diarrhea,
dry mouth, headache, nervousness, nausea, anorexia, heartburn, weakness,
polyuria and dysuria and rarely, excitability in children.
Pseudoephedrine HCI: Convulsions, CNS stimulations, cardiac arrhythmias,
respiratory difficulty, increased heart rate or blood pressure,
hallucinations, tremors, nervousness, insomnia, weakness, pallor and dysuria.
Contraindication(s)
Became Tablet is contraindicated in patients with lower respiratory tract
diseases which include asthma, severe hypertension, severe coronary artery
disease and patients on monoamine oxidase (MAO) inhibitor therapy and
patients with urinary retention, peptic ulcer.
Symptoms and Treatment for Overdosage, and Antidote(s)
In severe overdosage, the stomach should be emptied by aspiration and lavage.
Emetic may be tried if the patient is alert and there are no symptoms of
toxicity. Activated charcoal can be given.
Storage Condition(s)
Keep in a tight container.
Store at temperature below 30°C.
Protect from light and moisture.
Shelf-Life
3 years from the date of manufacture.
Packing(s)
Plastic bottle of 1000's.
Blister packing of 10's x 10 and 10's x 100. |
