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Became

Ingredient(s)
Each tablet contains:
Carbinoxamine Maleate .......................4mg
Pseudoephedrine HCI ........................60mg

Action(s)
1. Carbinoxamine Maleate is used in the treatment of allergy. Act by competing with histamine for H1-receptor sites on effector cells. They thereby prevent but do not reverse response mediated by histamine alone. The antimuscarinic actions of most antihistamine provide a drying effect on the nasal mucosa.

2. Pseudoephedrine HCI is a decongestantsympathomimetic amines act on alpha-adrenergic receptors in the mucosa of the respiratory tract to produce vasoconstriction which temporarily reduces the swelling associated with inflammation of the mucous membranes lining the nasal passages.

3. Carbinoxamine Maleate and Pseudoephedrine are well absorbed from the gastrointestinal tract after oral administration. Pseudoephedrine is incompletely metabolized in the liver. It has a half-life of 4.5 to 8 hours and has an onset of action within 30 minutes. Its duration of action is 4 to 6 hours. It is primarily excreted in the urine. Carbinoxamine has a half-life of 10 to 20 hours. Its duration of action is 3 to 6 hours with an onset of action within 15 to 60 minutes.

Indication(s)
For the relief of seasonal and allergic rhinitis and vasomotor rhinitis symptoms, such as sneezing, stuff nose and running nose.

Dosage and Administration
Adults: 1 tablet, given 3 to 4 times a day.

Children:
6 years and above: I tablet, given 3 to 4 times a day.
18 months to 6 years: 1/2 tablet, given 3 to 4 times a day.

Precaution(s) / Warning(s)
1. Should be used with caution in patients who may be hypersusceptible to their effects particularly those with hyperthyroidism and great care for patients with cardiovascular disease.

2. Care is also required when given to patients with diabetes mellitus or closed-angle glaucoma.

3. Should not be given to premature infants or neonate. 4. Safety use during pregnancy has not been established. 5. Should be used with caution in nursing mothers.

Side Effect(s) / Adverse Reaction(s)
Carbinoxamine Maleate: Sedation, dizziness, diplopia, vomiting, diarrhea, dry mouth, headache, nervousness, nausea, anorexia, heartburn, weakness, polyuria and dysuria and rarely, excitability in children.

Pseudoephedrine HCI: Convulsions, CNS stimulations, cardiac arrhythmias, respiratory difficulty, increased heart rate or blood pressure, hallucinations, tremors, nervousness, insomnia, weakness, pallor and dysuria.

Contraindication(s)
Became Tablet is contraindicated in patients with lower respiratory tract diseases which include asthma, severe hypertension, severe coronary artery disease and patients on monoamine oxidase (MAO) inhibitor therapy and patients with urinary retention, peptic ulcer.

Symptoms and Treatment for Overdosage, and Antidote(s)
In severe overdosage, the stomach should be emptied by aspiration and lavage. Emetic may be tried if the patient is alert and there are no symptoms of toxicity. Activated charcoal can be given.

Storage Condition(s)
Keep in a tight container.

Store at temperature below 30C.

Protect from light and moisture.

Shelf-Life
3 years from the date of manufacture.

Packing(s)
Plastic bottle of 1000's.
Blister packing of 10's x 10 and 10's x 100.

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