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Beprosone Cream

Betamethasone Dipropionate 0.064% Cream

 

DESCRIPTION:

White cream containing 0.064 % w/w of Betamethasone dipropionate (equivalent to 0.05% w/w betamethasone) with Chlorocresol 0.1% as preservative.

 

ACTIONS:

Betamethasone dipropionate is a topically active fluorinated corticosteroid which has anti-inflammatory, antipruritic and vasoconstrictive actions.

 

PHARMACOLOGY:

Corticosteroids are extensively bound to plasma protein. Only unbound corticosteroids have pharmacological effects or are metabolised. They are metabolised mainly in the liver and also in the kidney, and are excreted in the urine.

 

INDICATIONS:

Suppression of skin diseases in which inflammation is a prominent feature, e.g. eczema, infantile eczema, atopic dermatitis, dermatitis herpetiformis, contact dermatitis, neurodermatitis, psoriasis and intertrigo.

 

CONTRAINDICATIONS:

Hypersensitivity to betamethasone dipropionate, other corticosteroids. or any component in the base.

 

DRUG INTERACTIONS: Not known.

 

ADVERSE EFFECTS:

Reported local adverse reactions are burning sensation, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, maceration of the skin, secondary infection, skin atrophy, striae and miliria.

 

PRECAUTIONS/WARNINGS:

Discontinue use if irritation or sensitivity reaction develops and institute appropriate treatment. Corticosteroid applied to the skin can be absorbed in sufficient amounts to produce systemic effects such as hypothalamic-pituitary-adrenal axis suppression, manifestation of Cushing's syndrome, hyperglycaemia and glucosuria. Thus suitable precautions should be taken during prolonged treatment, when treating extensive body surface areas, when using the occlusive technique and when treating children (because of a larger skin surface area to bodyweight ratio). Safety of use of topical corticosteroids during pregnancy and lactation has not been established.

 

RECOMMENDED DOSAGE:

Apply a thin film to the affected skin areas once or twice daily as directed by your doctor or pharmacist. Treatment should be limited to 45 grams per week.

 

OVERDOSAGE:

If hypothalamic-pituitary-adrenal axis suppression is found, than the drug should be withdrawn frequency of application reduced or a weaker steroid used, Supplemental systemic corticosteroids may be required if signs and symptoms of steroid withdrawal occur.

 

PACKING:

Plastic jar of 450g and collapsible aluminium tube of 15g.

 

STORAGE:

Keep container well closed. Protect from strong light. Store below 30C. For external use only Keep out of reach of children. Recommended shelf-life: 3 years.

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