Oblong, blue uncoated tablet,
bevel-edged, flat faces, "HD" and break-bar embossed on the same face.
Papain equivalent to 26,000 USP
Units per tablet.
Actions and Pharmacology
Papain consists chiefly of a
mixture of papain and chymopapain, proteolytic enzymes which hydrolyse
polypeptides, amides and esters. It has a wider range of activity and is
more difficult to destroy than either trypsin or pepsin.
Oral use is indicated for
prevention of adhesions in sloughing and infected wounds; and for treatment
of oedema and inflammatory conditions.
- Not recommended for patients with
generalised or systemic infections or with disorders of blood coagulation.
- Avoid concurrent use with
Safety for use in pregnancy and
lactation has not been established.
Main Side/Adverse Effects
Urticaria, pruritus, dizziness,
nausea, vomiting, diarrhoea and sensitisation may occur.
Dosage and Administration
Adults : Oral, 2 tablets sucked
or chewed 4 times daily for the 1st day, followed by 1 tablet 4 times daily
for about 5 days.
Children : As directed by