1 g ointment contains: 10 mg chloramphenicol.
Other ingredients: liquid paraffin and white vaseline.
The active ingredient is chloramphenicol, which has a broad antimicrobial
spectrum of activity, especially against the gram-negative and gram-positive
microorganisms, such as Escherichia coli, Haemophilus influenzae,
Staphylococcus aureus, Streptococcus hemolyticus and Moraxella lacunata (Morax-Axenfeld
bacillus), Rickettsia, Chlamydia and Brucella.
Chloramphenicol is used for the treatment of superficial infections of the
conjunctiva and cornea caused by microorganisms susceptible to
The clinical indications are: bacterial blepharitis, conjunctivitis,
keratitis, and infections following injuries to the conjunctiva and cornea.
Hypersensitivity to the drug and severe bone marrow damages, also in
Chloramphenicol is mainly used for infections caused by agents resistant to
other antibiotic drugs.
As with other antibiotics, long-term use of chloramphenicol may lead to
superinfection with non-susceptible strains of microorganisms, which
requires a change of medicament. If no clinical improvement is achieved
within the expected time, the treatment should be withdrawn and another drug
Chloramphenicol is not used in children under the age of two years.
During treatment patients should not wear contact lenses.
Concomitant treatment with penicillin and chloramphenicol reduces their
Pregnancy and lactation
Only short-term treatment is allowed in prescribed doses if the expected
benefit justifies the risk.
Long-term treatment with Chloramphenicol eye ointment or frequent repetition
of treatment is not recommended.
The ointment may temporarily reduce visual acuity. Patients should not
operate vehicles or machines until they regain complete clarity of vision.
Considering the severity of infection, a small amount of ointment (approx. 1
cm) is applied into the lower conjunctival sac every 3-4 hours within the
first 48 hours. After two days of treatment, the interval between the doses
may be prolonged. Chloramphenicol primarily exerts bacteriostatic action,
therefore the treatment must be continued for 48 hours after withdrawal of
In some patients hypersensitive reactions may occur, e.g. a burning
sensation, pruritus, angioneurotic edema, urticaria, and vesicular and
maculopapular dermatitis. With topical application, toxic effects on the
bone marrow occur very rarely in the form of blood dyscrasias. These effects
are generally dose-dependent and reversible. This type of toxic reactions
mainly occurs in systemic use of chloramphenicol. With topical application,
aplastic anaemia may rarely occur after several months or even several years
of use, or after frequent intermittent use. In such cases the treatment with
chloramphenicol should be withdrawn.
No cases of topical overdosage or ointment ingestion have been reported.
There is no specific antidote.
Storage and expiry date
The drug should not be used after the expiry date shown on the packaging.
Do not store over 30°C. Keep out of the reach of children.
On physician's prescription only.
5 g of eye ointment