Medical  Explorer

Custom Search

Drugs A to Z  :  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  R  S  T  U  V  W  X  Y  Z
Medicinal Ingredients : A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Beauty Products : A  B  C  D  E  F  G  I  M  N  O  P  R  S  T  V

Aging      Allergies     Alzheimer's      Arthritis    Asthma      Bacteria   new Cancer    Chickenpox     Colds     Constipation      Diabetes      Epilepsy     Fatigue     Fever     Genetics       Haemorrhoids       newHeadaches      Hepatitis    Immunity      Infection      Insomnia       Leprosy       Menopause      Obesity      Osteoporosis     Other Diseases    Pain      PMS     Parasites     Sinusitis     newStroke     Toxicology    Urology




Arthritis medications
Acupuncture
Alcohol
Patients
newGeneral Health
Medicinal food
Chinese medicine
Nutrients
Smoking
Vitamins
OTC Drugs
Health Products
Therapy
Symptom
Parasitology
 
 

Chloramphenicol
Eye ointment

 

Composition

1 g ointment contains: 10 mg chloramphenicol.

Other ingredients: liquid paraffin and white vaseline.


Action

The active ingredient is chloramphenicol, which has a broad antimicrobial spectrum of activity, especially against the gram-negative and gram-positive microorganisms, such as Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Streptococcus hemolyticus and Moraxella lacunata (Morax-Axenfeld bacillus), Rickettsia, Chlamydia and Brucella.


Indications

Chloramphenicol is used for the treatment of superficial infections of the conjunctiva and cornea caused by microorganisms susceptible to chloramphenicol.


The clinical indications are: bacterial blepharitis, conjunctivitis, keratitis, and infections following injuries to the conjunctiva and cornea.


Contraindications

Hypersensitivity to the drug and severe bone marrow damages, also in history.


Precautions

Chloramphenicol is mainly used for infections caused by agents resistant to other antibiotic drugs.


As with other antibiotics, long-term use of chloramphenicol may lead to superinfection with non-susceptible strains of microorganisms, which requires a change of medicament. If no clinical improvement is achieved within the expected time, the treatment should be withdrawn and another drug introduced.

 

Chloramphenicol is not used in children under the age of two years.


During treatment patients should not wear contact lenses.


Interactions

Concomitant treatment with penicillin and chloramphenicol reduces their antimicrobial action.


Pregnancy and lactation

Only short-term treatment is allowed in prescribed doses if the expected benefit justifies the risk.


Special precautions

Long-term treatment with Chloramphenicol eye ointment or frequent repetition of treatment is not recommended.


The ointment may temporarily reduce visual acuity. Patients should not operate vehicles or machines until they regain complete clarity of vision.


Dosage

Considering the severity of infection, a small amount of ointment (approx. 1 cm) is applied into the lower conjunctival sac every 3-4 hours within the first 48 hours. After two days of treatment, the interval between the doses may be prolonged. Chloramphenicol primarily exerts bacteriostatic action, therefore the treatment must be continued for 48 hours after withdrawal of symptoms.


Side effects

In some patients hypersensitive reactions may occur, e.g. a burning sensation, pruritus, angioneurotic edema, urticaria, and vesicular and maculopapular dermatitis. With topical application, toxic effects on the bone marrow occur very rarely in the form of blood dyscrasias. These effects are generally dose-dependent and reversible. This type of toxic reactions mainly occurs in systemic use of chloramphenicol. With topical application, aplastic anaemia may rarely occur after several months or even several years of use, or after frequent intermittent use. In such cases the treatment with chloramphenicol should be withdrawn.


Overdosage

No cases of topical overdosage or ointment ingestion have been reported. There is no specific antidote.


Storage and expiry date

The drug should not be used after the expiry date shown on the packaging.

Do not store over 30C. Keep out of the reach of children.


Prescribing information

On physician's prescription only.


Supply

5 g of eye ointment

Abdomen
Blood
Bone
Breast
Ear

Eye

Face
Hair

Head

Heart
Kidney
Liver
Limbs
Lungs
newMind
Mouth
Muscles
Nails

Neck

newNerves
Nose

Skin

Teeth

Throat

Tongue
 
Health news
 
Cardiovascular Guide
 
Natural Remedies
 
Treatment of Cancer
 
Women's Health
 
Irritable bowel syndrome
 
Common Childhood Illnesses
 
Prescribed Drugs
 
 

     
         
     

 

Disclaimer