Medical  Explorer

Custom Search

Drugs A to Z  :  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  R  S  T  U  V  W  X  Y  Z
Medicinal Ingredients : A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Beauty Products : A  B  C  D  E  F  G  I  M  N  O  P  R  S  T  V

Aging      Allergies     Alzheimer's      Arthritis    Asthma      Bacteria   new Cancer    Chickenpox     Colds     Constipation      Diabetes      Epilepsy     Fatigue     Fever     Genetics       Haemorrhoids       newHeadaches      Hepatitis    Immunity      Infection      Insomnia       Leprosy       Menopause      Obesity      Osteoporosis     Other Diseases    Pain      PMS     Parasites     Sinusitis     newStroke     Toxicology    Urology




Arthritis medications
Acupuncture
Alcohol
Patients
newGeneral Health
Medicinal food
Chinese medicine
Nutrients
Smoking
Vitamins
OTC Drugs
Health Products
Therapy
Symptom
Parasitology
 
 

Chlorpheniramine

COMPOSITION
Each tablet contains
Chlorpheniramine Maleate ... 4mg

PRESENTATION
An orange, biconvex, round tablet 8 mm in diameter with KOTRA logo on one side and a single score line on the other side.

INDICATIONS
For allergic conditions including hay fever, urticaria, angioedema, vasomotor rhinitis, allergic, eczema, atopic and contact dermatitis, drug and serum reactions, insect bites, pruritus.

MECHANISMS OF ACTION
Chlorpheniramine Maleate is an alkylamine derivative with antihistamine and anticholinergic effects. The antihistamine acts by competing with histamine for H1 receptor sites on the effector cells to the exclusion of agonist molecules, without itself initiating a response. This antagonism is competitive and reversible. It does not prevent the production of histamines.

PHARMACOLOGY:
Chlorpheniramine Maleate is readily absorbed from gastrointestinal tract and parenteral sites of administration. Following oral administration the effects may start within 15 to 30 minutes, reaching peak within 1 hour, and may last about 4-6 hours. It is extensively metabolised in the liver, and excreted mainly as metabolites in the urine.

DOSAGE
Adults: 1 tablet 3 or 4 times daily.
Children 6-12 years: 1/2 tablet (2mg) 3-4 times daily.

CONTRAINDICATIONS
Contraindicated in patients with known sensitivity to antihistamines.

SIDE EFFECTS
The most common side effect is sedation, varying from drowsiness to deep sleep, and including inability to concentrate, lassitude, dizziness, hypotension, muscular weakness and inco-ordination. Sedative effects, when they occur, may diminish after a few day. Other side effects include gastrointestinal disturbances, such as nausea, vomiting, diarrhea or constipation, colic, and epigastric pain. It may also produce headache, blurred vision, tinnitus, elation or depression, irritability, nightmares, anorexia, difficulty in micturition, dryness of mouth, tightness of chest, tingling, heaviness and weakness of the hands. It may potentiate CNS depressants. Large doses may precipitate fits in epileptics.

PRECAUTION
May cause drowsiness and hence may impair ability to drive vehicles or operate machinery. MAO inhibitors may prolong some of its actions. Patients should be warned that antihistamine may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, narcotic analgesics, sedatives and tranquillisers. Use with caution in patients with narrow angle glaucoma, history of bronchial asthma, hyperthyroidism, cardiovascular disease and prostatic hypertrophy. Use is not recommended in nursing mothers, pregnancy, newborn and premature infants. Safety and efficacy of the drug in children younger than 2 years of age have not been established.

DRUG INTERACTIONS
MAO inhibitors may enhance the antimuscarinic effects of chlorpheniramine while CNS depressants including alcohol, barbiturates, hypnotics, narcotic analgesics, sedatives and tranquillisers may enhance the sedative effects. It is also important to note that chlorpheniramine may mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibiotics.

TREATMENT FOR OVERDOSAGE
If the drug has been taken recently by mouth, the stomach should be emptied by aspiration and lavage. Emetics are generally of little value. The patients should be kept quiet to minimise the excitation which occurs particularly in children. Convulsions and marked CNS stimulation should preferably be treated with diazepam or phenobarbitone intramuscularly, paraldehyde, thiopentone sodium, and chlorpromazine have also been recommended. Severe hypotension may require fluid replacement, and assisted respiration may be necessary. Forced diuresis is of little value since antihistamines are rapidly metabolised and only traces are recovered in the urine.

STORAGE
Keep container well closed. Store below 30C. Protect from light.

PACKAGE QUANTITIES

Available in plastic container of 1000 tablets and blister pack of 100 x 10's & 10 x 10's.

Abdomen
Blood
Bone
Breast
Ear

Eye

Face
Hair

Head

Heart
Kidney
Liver
Limbs
Lungs
newMind
Mouth
Muscles
Nails

Neck

newNerves
Nose

Skin

Teeth

Throat

Tongue
 
Health news
 
Cardiovascular Guide
 
Natural Remedies
 
Treatment of Cancer
 
Women's Health
 
Irritable bowel syndrome
 
Common Childhood Illnesses
 
Prescribed Drugs
 
 

     
         
     

 

Disclaimer