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COUMADIN

 

Contents:

Warfarin sodium.

 

Indications:

Venous thrombosis & its extension, atrial fibrillation with embolization, pulmonary embolism & as adjunct in treatment of coronary occlusion.

 

Dosage:

Induction with 10-15 mg daily ( usually 2 or 4 days), then adjust according to prothrombin time. Maintenance: 2-10 mg daily

 

Contraindications:

Pregnancy; hemorrhagic tendency or blood dyscrasias; recent or contemplated surgery of CNS, eye; traumatic surgery resulting in large open surfaces; bleeding tendencies associated with active ulceration or overt bleeding; threatened abortion; spinal puncture.

 

Special Precautions:

Haemorrhage. Periodic determination or prothrombin time is essential. Necrosis &/or gangrene of skin & other tissue. Known or suspected hereditary, familial or clinical deficiency in protein C has been associated with an increased risk of developing  necrosis during warfarin administration.

 

Adverse Reactions:

Hemorrhage, necrosis of skin or other tissues.

Infrequently

Alopecia, urticaria, dermatitis, fever, gastrointestinal disturbances, abdominal cramps, 'purple toes' syndrome, cholestatic hepatic injury.

 

Drug interactions:

Effects diminished by barbiturates, cholestyramine, glutethimide, rifampicin, vitamin K, griseofulvin, carbamazepine, ethchlorvynol. Effects enhanced by phenylbutazone, anabolic steroids, chloral hydrate, cimetidien, clofibrate, d-thyroxine, diflunisal, disulfiram, mefenamic acid, metronidazole, quinidine. Interferes with metabolism or excretion of hypoglycemic agents & anticonvulsants.

 

Presentation/Packing

Tab 2 mg x 100's. 5 mg x 100's.

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