Venous thrombosis & its
extension, atrial fibrillation with embolization, pulmonary embolism & as
adjunct in treatment of coronary occlusion.
Induction with 10-15 mg daily (
usually 2 or 4 days), then adjust according to prothrombin time.
Maintenance: 2-10 mg daily
Pregnancy; hemorrhagic tendency
or blood dyscrasias; recent or contemplated surgery of CNS, eye; traumatic
surgery resulting in large open surfaces; bleeding tendencies associated
with active ulceration or overt bleeding; threatened abortion; spinal
determination or prothrombin time is essential. Necrosis &/or gangrene of
skin & other tissue. Known or suspected hereditary, familial or clinical
deficiency in protein C has been associated with an increased risk of
developing necrosis during warfarin administration.
Hemorrhage, necrosis of skin or
Alopecia, urticaria, dermatitis,
fever, gastrointestinal disturbances, abdominal cramps, 'purple toes'
syndrome, cholestatic hepatic injury.
Effects diminished by
barbiturates, cholestyramine, glutethimide, rifampicin, vitamin K,
griseofulvin, carbamazepine, ethchlorvynol. Effects enhanced by
phenylbutazone, anabolic steroids, chloral hydrate, cimetidien, clofibrate,
d-thyroxine, diflunisal, disulfiram, mefenamic acid, metronidazole,
quinidine. Interferes with metabolism or excretion of hypoglycemic agents &
Tab 2 mg x 100's. 5 mg x 100's.