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DYNA amoxycillin
 

 

Description

Content

Dyna Amoxycillin

125 mg / 5 ml

Dry Syrup

Colour: White

(Pink on adding water)

Flavour: Strawberry

Each 5 ml of the reconstituted suspension contains:

Amoxycillin Trihydrate equivalent to amoxycillin 125 mg

Preservative: Sodium Benzoate ......................... 0.1 % w/v

Dyna Amoxycillin

250 mg / 5 ml

Dry Syrup

Colour: White

(Pink on adding water)

Flavour: Strawberry

 

Each 5 ml of the reconstituted suspension contains:

Amoxycillin Trihydrate equivalent to amoxycillin 250 mg

Preservative: Sodium Benzoate ......................... 0.1 % w/v

 


PHARMACODYNAMICS:
Amoxycillin is a bactericidal antibiotic which inhibits bacterial cell wall synthesis, probably by acylation of membrane-bound transpeptidease enzymes. This prevents cross-linkage of peptidoglycan chains which is necessary for bacterial cell wall strength and rigidity. Also, cell division and growth are inhibited and lysis of susceptible bacteria frequently occurs. Rapidly dividing bacteria are most susceptible to penicillin group of antibiotics including Amoxycillin.

PHARMACOKINETICS
Amoxycillin is stable to gastric acid and 50 to 90% of a dose is absorbed after oral administration; absorption is more complete than that of Ampicillin and it is not greatly influenced by the presence of food. After an oral dose of 500 mg, peak serum concentrations of 3 to 20 mcg/ml are attained in 1 to 2 hours; detectable concentrations are present after 8 hours; peak concentrations occur earlier in children and infants but later in neonates. Serum half-life is I hour which may be increased to 15 hours in renal failure. After absorption, Amoxycillin enters most tissues and fluids but it is not detectable in the cerebrospinal fluid even when the meninges are inflamed; crosses the placenta and small amounts are secreted in the milk; volume of distribution at steady-state serum concentrations, about 0.3 litres/kilogram body-weight; protein binding, 15 to 25% bound to plasma proteins. Amoxycillin is metabolised to inactive metabolites and 10 to 25% appears to be converted to penicilloic acid. 35 to 45% is excreted in the urine after an oral dose and about 75% after intramuscular or intravenous doses; urinary excretion is delayed by probenecid and it also occurs more slowly in the newborn; small amounts are excreted in the bile.

INDICATIONS
Infections e.g. otitis media, sinusitis, pharyngitis, pneumonia, bronchitis caused by sensitive gram-positive organisms, including Streptococcus pneumoniae, and other streptococci and Listeria monocytogenes. Gram-negative microorganism including some of strains of Bordetella pertussis, Haemophilus influenzae and some Enterobacteriaceae such as Escherichia coli, Proteus mirabilis, Salmonella and Shigella slap..

ENT infections: otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis, epiglottis.

Lower respiratory tract infections: acute and chronic bronchitis, pneumonia, pleuritis.

Urinary tract infections: acute and recurrent cystitis, acute and chronic pyelonephritis, asymptomatic bacteriuria, prostitis.

Skin and soft tissue infections: erysipelas, impetigo.

 

RECOMMENDED DOSAGE

Dyna Amoxycillin

125 mg / 5 ml

 

Adults : 10 ml (2 teaspoonfuls) 3 times daily.
Children : 5 ml (1 teaspoonful) 3 times daily, increasing to 10 ml (2 teaspoonfuls) 3 times daily for more severe infections.
Dyna Amoxycillin

255 mg / 5 ml

Adults : 5 ml (1 teaspoonfuls) 3 times daily.
Children : 2.5 ml (1/2 teaspoonful) 3 times daily, increasing to 5 ml (1 teaspoonfuls) 3 times daily for more severe infections.

Gonorrhoea : A single dose of 3 g plus 1 g of probenecid where infection is caused by penicillin-sensitive organisms.
Note:

* Patients should continue medicine for full course of treatment.

* Take medicine on empty stomach.
* Reduce dosage is required in patients with impaired renal function.


DIRECTION FOR MIXING
Shake to loosen powder. Add approximately half the final volume (30 ml or 50 ml) of freshly boiled and cooled water and shake gently.
Add more water until the final volume (60 ml or 100 ml) mark is reached and shake well.

Keep refrigerated and to be used within 7 days of mixing.

Complete the prescribed course.

CONTRAINDICATIONS
Not to be used in patients with known hypersensitivity to penicillin.

PRECAUTIONS/WARNINGS
Patients hypersensitive to other penicillins or cephalosporins or penicillamine may be hypersensitive to Amoxycillin.

DRUG INTERACTIONS
Probenecid prolongs blood levels of Amoxycillin. Antacids and other alkanising agents can impair absorption of Amoxycillin. May reduce effectiveness of oral contraceptives. Concurrent administration of Amoxycillin and Allopurinol increases incidence of rashes.

PREGNANCY & LACTATION
Risk-benefit must be considered when given to pregnant women and during breast-feeding.

SIDE EFFECTS/ADVERSE REACTIONS
Side effects are usually mild and transitory e.g. nausea, vomiting, diarrhoea, indigestion. Amoxycillin may give rise to a rash which may be of toxic origin. Rashes almost invariably result when Amoxycillin is given to patients with glandular fever. Small amounts of Amoxycillin excreted in the milk may provoke allergic reactions in breast-fed infants.
Pseudomembranous colitis e.g. severe abdominal or stomach cramps and pain; abdominal tenderness; watery and severe diarrhoea, which may be bloody; fever.

SYMPTOMS AND TREATMENT OF OVERDOSE
Problems of overdosage are unlikely to be encountered. Gross overdosage will produce very high urinary concentration, more so after parenteral administration. Problems are unlikely if adequate fluid intake and urinary output are maintained; however crystalluria is a possibility. More specific measures may be necessary in patients with impaired renal function; the antibiotic is removed by haemodialysis.

PACKING/PACK SIZES
Plastic bottles of 60 ml and 100 ml.

SHELF LIFE
3 years from the date of manufacture.


STORAGE CONDITIONS
Keep out of reach of children

Keep container tightly closed

Store in a dry place below 25C

Protect From Light

Shake well before use

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