Orange, Oblong, biconvex,
top-scored and film-coated tablet
Each tablet contains:
Diosmin (micronised) 450.0 mg
Hesperidin (micronised) 50.0 mg
For hemorrhoids and chronic venous insufficiency of the lower limbs with
symptoms like heavy legs, pain, nocturnal cramps and varicose veins.
Diosmin and hesperidin are bioflavonoids found in many citrus fruits. The
bioflavonoids reinforce venous tone by prolonging the activity of parietal
noradrenaline, thus reduces venous distensibility and venous status.
The bioflavonoids also combat venous inflammation by inhibiting the release
of its mediators, principally free radicals and prostaglandins. Thus, it
normalizes capillary resistance.
Breastfeeding is not recommended during treatment. Patients who are
hypersensitive to the bioflavonoids should be contraindicated.
Side effects/Adverse reactions
Some cases of minor gastrointestinal and autonomic disorders have been
reported, which never required cessation of treatment.
No teratogenic effects have been shown in animals and no harmful effect in
human beings has been reported.
However, breast-feeding is not recommended during treatment, as there is no
data related to diffusion into the
In acute hemorrhoidal episodes, physician must be consulted if hemorrhoid
symptoms do not disappear within two weeks.
Dosage and administration
Acute hemorrhoidal attacks : 3 tablets twice daily for 4 days, then 2
tablets twice daily.
Chronic hemorrhoids and venous insufficiency : 2 tablets daily with
meal, midday and evening.
Treatment of overdosage
Minor gastrointestinal discomfort may occur. Treatment is symptomatic and
Storage Conditions : Keep container tightly closed. Store in a dry place
below 30°C. Protect from light.
Keep away from children.
Presentation : 30's/ box.
Shelflife : 3 years.