Medical  Explorer

Custom Search

Drugs A to Z  :  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  R  S  T  U  V  W  X  Y  Z
Medicinal Ingredients : A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Beauty Products : A  B  C  D  E  F  G  I  M  N  O  P  R  S  T  V

Aging      Allergies     Alzheimer's      Arthritis    Asthma      Bacteria   new Cancer    Chickenpox     Colds     Constipation      Diabetes      Epilepsy     Fatigue     Fever     Genetics       Haemorrhoids       newHeadaches      Hepatitis    Immunity      Infection      Insomnia       Leprosy       Menopause      Obesity      Osteoporosis     Other Diseases    Pain      PMS     Parasites     Sinusitis     newStroke     Toxicology    Urology




Arthritis medications
Acupuncture
Alcohol
Patients
newGeneral Health
Medicinal food
Chinese medicine
Nutrients
Smoking
Vitamins
OTC Drugs
Health Products
Therapy
Symptom
Parasitology
 
 

Dopatab M

 

Composition

Methyldopa equivalent to Anhydrous Methyldopa 125 mg or 250 mg per tablet.

 

Actions and Pharmacology

Exact mechanism of antihypertensive actions is currently thought to involve stimulation of central alpha-adrenergic receptors by a metabolite, alpha-methytnorepinephrine, thus inhibiting sympathetic outflow to the heart, kidneys, and peripheral vasculature. Reduced peripheral resistance and plasma renin activity levels may also contribute to its effect. Oral absorption is incomplete and excretion is via urine and faeces.

 

Indication

For treatment of moderate to severe hypertension.

 

Contraindication

Not recommended for patients with acute liver disease or phaeochromocytoma.

 

Precautions

  - Evidence of hemolytic anaemia is an indication for discontinuing the drug.

  - Positive Coombs' tests may indicate an incompatible cross-match when transfusion is required and an indirect Coombs' test should be carried out.

  - Safety for use in pregnancy and lactation has not been established.

  - Caution it any kind of surgery or dialysis is required.

 

Main Side/Adverse Effects

Drowsiness, edema, dry mouth and headache.

 

Drug Interactions

  - Concurrent use with the following drugs is not recommended:

     Monoamine oxidase (MAO) inhibitors, levodopa and methotrimeprazine.

  - Concurrent use with the following drugs requires careful monitoring:

    Alcohol, antihypertensives, general anaesthetics and norepinephrine.

 

Overdosage

Clinical features . Dizziness, drowsiness, hypotension, tachycardia or bradycardia, hypothermia, extra-pyramidal signs, coma.

 

Treat overdosage by emesis or gastric lavage, if appropriate; and IV 1-2 mg benztropine if extrapyramidal signs are present.

 

Dosage and Administration

Adults

Initial - Oral, 250 mg two or three times a day for two days, the dosage then being adjusted as directed.

Maintenance - Oral, 500 mg to 2 g a day, divided into two to four doses, not exceeding 3 g daily.

 

Children

Oral, initially 10 mg per kg of body weight daily, divided into two to four doses, the dosage then being adjusted as directed, not exceeding 65 mg per kg of body weight or 3 g daily, whichever is less.

 

Storage

Store below 25C. Protect from light. Presentation/Packing : Film-coated tablet 125 mg x 1000's; 250 mg x 1000's, Blisters 10 x 10's.

Abdomen
Blood
Bone
Breast
Ear

Eye

Face
Hair

Head

Heart
Kidney
Liver
Limbs
Lungs
newMind
Mouth
Muscles
Nails

Neck

newNerves
Nose

Skin

Teeth

Throat

Tongue
 
Health news
 
Cardiovascular Guide
 
Natural Remedies
 
Treatment of Cancer
 
Women's Health
 
Irritable bowel syndrome
 
Common Childhood Illnesses
 
Prescribed Drugs
 
 

     
         
     

 

Disclaimer