Medical  Explorer

Custom Search

Drugs A to Z  :  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  R  S  T  U  V  W  X  Y  Z
Medicinal Ingredients : A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Beauty Products : A  B  C  D  E  F  G  I  M  N  O  P  R  S  T  V

Aging      Allergies     Alzheimer's      Arthritis    Asthma      Bacteria   new Cancer    Chickenpox     Colds     Constipation      Diabetes      Epilepsy     Fatigue     Fever     Genetics       Haemorrhoids       newHeadaches      Hepatitis    Immunity      Infection      Insomnia       Leprosy       Menopause      Obesity      Osteoporosis     Other Diseases    Pain      PMS     Parasites     Sinusitis     newStroke     Toxicology    Urology




Arthritis medications
Acupuncture
Alcohol
Patients
newGeneral Health
Medicinal food
Chinese medicine
Nutrients
Smoking
Vitamins
OTC Drugs
Health Products
Therapy
Symptom
Parasitology
 
 

Exforge HCT

Angiotensin II antagonists combinations plain (valsartan) with dihydropyridine derivatives (amlodipine) and thiazide diuretics (HCTZ)

 

COMPOSITION AND PHARMACEUTICAL FORM

Active substances:

Amlodipine besylate: 3-Ethyl-5-methyl()-2-[(2-minoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate,mono-benzenesulphonate.

Valsartan: (S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-valine.

Hydrochlorothiazide: 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide.

 

Five strengths are available. One tablet of Exforge HCT contains:

- 5 mg of amlodipine ( equivalent to 6.94 mg amlodipine besylate), 160 mg of valsartan and 12.5 mg hydrochlorothiazide

- 10 mg of amlodipine ( equivalent to 13.87 mg amlodipine besylate), 160 mg of valsartan and 12.5 mg hydrochlorothiazide

- 5 mg of amlodipine ( equivalent to 6.94 mg amlodipine besylate), 160 mg of valsartan and 25 mg hydrochlorothiazide

- 10 mg of amlodipine ( equivalent to 13.87 mg amlodipine besylate), 160 mg of valsartan and 25 mg hydrochlorothiazide

- 10 mg of amlodipine ( equivalent to 13.87 mg amlodipine besylate), 320 mg of valsartan and 25 mg hydrochlorothiazide

For a full list of excipients, see section EXCIPIENTS.

 

Certain dosage strengths and dosage forms may not be available in all countries.

 

Exforge HCT 5/160/12.5mg: White, biconvex, ovaloid film-coated tablet with bevelled edge, debossed with "NVR" on one side and "VCL on the other side.

Exforge HCT 10/160/12.5mg: Pale yellow, biconvex, ovaloid film-coated tablet with bevelled edge, debossed with "NVR" on one side and "VDL on the other side.

Exforge HCT 5/160/25mg: Yellow, biconvex, ovaloid film-coated tablet with bevelled edge, debossed with "NVR" on one side and "VEL on the other side.

Exforge HCT 10/160/25mg: Brown-yellow, biconvex, ovaloid film-coated tablet with bevelled edge, debossed with "NVR" on one side and "VHL on the other side.

Exforge HCT 10/320/25mg: Brown-yellow, biconvex, ovaloid film-coated tablet with bevelled edge, debossed with "NVR" on one side and "VFL on the other side.

 

INDICATIONS

Treatment of essential hypertension.

This fixed combination drug is not indicated for the initial therapy of hypertension ( See section DOSAGE AND ADMINISTRATION ).

 

DOSAGE AND ADMINISTRATION

The recommended dose is one tablet per day ( the 5 strengths are listed in section COMPOSITION AND PHARMACEUTICAL FORM ).

 

A patient whose blood pressure is not adequately controlled on dual therapy may be directly switched to combination therapy with Exforge HCT.

 

For convenience, patients receiving valsartan, amlodipine and HCTZ from separate tablets may be switched to Exforge HCT containing the same component doses. A patient who experiences dose limiting adverse reactions on any dual combination of the components of Exforge HCT may be switched to Exforge HCT containing a lower dose of that component to achieve similar blood pressure reductions.

 

Dosage may be increased after two weeks. The maximum antihypertensive effect of Exforge HCT is reached within two weeks after a change in dose. The maximum recommended dose of Exforge HCT is 10/320/25mg.

 

Exforge HCT can be taken with or without food. It is recommended to take Exforge HCT with some water.

 

In Elderly

No adjustment of the initial dose is required for elderly patients ( See section PHARMACOKINETICS ).

 

Children and adolescents ( below 18 years )

Exforge HCT is not recommended for use in patients aged below 18 years due to a lack of data on safety and eficacy.

 

Renal and hepatic impairment

No dosage adjustment is required for patients with mild to moderate renal impariment but caution should be exercised when administering Exforge HCT to patients with hepatic impairment or biliary obstructive disoders ( see section SPECIAL WARNINGS AND PRECAUTIONS FOR USE ). Due to the hydrochlorothiazide component, Exforge HCT is not recommended in patients with severe renal impairment ( creatinine clearance < 30 mL/min ) and in patients with severe hepatic impariment ( See section CONTRAINDICATIONS and section PHARMACOKINETICS ).

 

CONTRAINDICATIONS

Hypersensitivity to amlodipine, valsartan, HCTZ, other sulfonamides or to any of the excipients.

 

Exforge HCT is contraindicated in pregnancy ( see section PREGNANCY AND LACTATION ). Because of hydrochlorothiazide, Exforge HCT is contraindicated in patients with severe hepatic impairment, severe renal impairment ( creatinine clearance < 30 mL/min ), anuria, refractory hypokalaemia, hyponatraemia, hypercalcaemia, and symptomatic hyperuricaemia.

 

1    2    3    4    5    6    7    8

Abdomen
Blood
Bone
Breast
Ear

Eye

Face
Hair

Head

Heart
Kidney
Liver
Limbs
Lungs
newMind
Mouth
Muscles
Nails

Neck

newNerves
Nose

Skin

Teeth

Throat

Tongue
 
Health news
 
Cardiovascular Guide
 
Natural Remedies
 
Treatment of Cancer
 
Women's Health
 
Irritable bowel syndrome
 
Common Childhood Illnesses
 
Prescribed Drugs
 
 

     
         
     

 

Disclaimer