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Eldoguin forte

ELDOGUIN FORTE 4% Cream (Hydroquinone USP, 4%)
(Skin Bleaching Cream)
ELDOPAQUE FORTE 4% Cream (Hydroquinone USP, 4%)
(Skin Bleaching Cream with Sunblock)
SOLAQUIN FORTE 4% Cream (Hydroquinone USP, 4%)
(Skin Bleaching Cream with Sunscreens, SPF 17)
SOLAQUIN FORTE 4% Gel (Hydroquinone USP, 4%)
(Skin Bleaching Gel with Sunscreens)

FOR EXTERNAL USE ONLY

DESCRIPTION
Hydroquinone is 1,4-benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C6H602; molecular weight 110.1.

The structural formula is:

eldoguin forte

Each gram of Eldoquin Forte 4% Cream contains 40 mg of Hydroquinone USP in a vanishing cream base of purified water USP, stearic acid NF, propylene glycol USP, polyoxyl 40 stearate NF, polyoxyethylene (25) propylene glycol stearate, glycerol monostearate, light mineral oil NF, squalane NF, propylparaben NF and sodium metabisulfite NF.

Each gram of Eldopaque Forte 4% Cream contains 40 mg of Hydroquinone USP in a tinted sunblocking cream base of purified water USP, stearic acid NF, talc USP, polyoxyl 40 stearate NF, polyoxyethylene (25) propylene glycol stearate, propylene glycol USP, glycerol monostearate, iron oxides, light mineral oil NF, squalane NF, edetate disodium USP sodium metabisulfite NF and potassium sorbate NF.

Each gram of Solaquin Forte 4% Cream contains 40 mg of Hydroquinone USP, 80 mg Padimate O USE 30 mg Dioxybenzone USP and 20 mg Oxybenzone USP in a vanishing cream base of purified water USP, glycerol monostearate and polyoxyethylene stearate, octyldodecyl stearoyl stearate, glyceryl dilaurate, quaternium-26, cetearyl alcohol and ceteareth-20, stearyl alcohol NF, propylene glycol USP, diethylaminoethyl stearate, polydimethylsiloxane, polysorbate 80 NF, lactic acid USP, ascorbic acid USP, hydroxyethyl cellulose, myristalkonium chloride and quaternium-14, edetate disodium USP and sodium metabisulfite NF

Each gram of Solaquin Forte 4% Gel contains 40 mg of Hydroquinone USP 50 mg of Padimate O USP and 30 mg Dioxybenzone USP, in a hydro-alcoholic base of alcohol USP, purified water USP, propylene glycol USP, entprol, carbomer 940, acetate disodium USP and sodium metabisulfite NF.

CLINICAL PHARMACOLOGY
Topical application of hydroquinone produces a reversible depigmentation of the skin by inhibition of the enzymatic oxidation of tyrosine to 3,4-dihydroxyphenylalanine (dopa) (Denton, C. et al., 1952)1 and suppression of other melanocyte metabolic processes (Jimbow, K. et al., 1974).2 Exposure to sunlight or ultraviolet light will cause repigmentation of bleached areas which may be prevented by the sunblocking agents contained in Eldopaque Forte 4% Cream and by the broad spectrum sunscreen agents contained in Solaquin Forte 4% Cream and Solaquin Forte 4% Gel (Parrish, J.A. et al., 1978).3

INDICATIONS AND USAGE
For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.

CONTRAINDICATIONS
Prior history of sensitivity or allergic reaction to these products or any of the ingredients. The safety of topical hydroquinone use during pregnancy or in children (12 years and under) has not been established.

WARNINGS
Caution: Hydroquinone is a skin bleaching agent which may produce unwanted cosmetic effects if rot used as directed. The physician should be familiar with the contents of the package insert before prescribing or dispensing these medications.

Test for skin sensitivity before using by applying a small amount to an unbroken patch of skin and check in 24 hours. Minor redness is not a contraindication, but where there is itching or vesicle formation or excessive inflammatory response, further treatment is not advised. Close patent supervision is recommended. Contact with the eyes should be avoided. If no bleaching or lightening effect is noted after 2 months of treatment use, the medication should be discontinued. Eldoquin Forte 4% Cream, Eldopaque Forte 4% Cream, Solaquin Forte 4% Cream and Solaquin Forte 4% Gel are formulated for use as skin bleaching agents and should not be used for the prevention of sunburn.

Sunscreen use is an essential aspect of hydroquinone therapy because even minimal sunlight sustains melanocytic activity. The sunblock in Eldopaque Forte 4% Cream and the sunscreens in Solaquin Forte 4% Cream and Solaquin Forte 4% Gel provide the necessary sun protection during skin bleaching therapy. After cleaning and during maintenance therapy, sun exposure should be avoided on bleached skin by application of a sunscreen or sunblock agent or protective clothing to p event repigmentation.

Keep this and all medication out of the reach of children. In case of accidental ingestion, call a physician or a poison control center immediately.

Warning: Contains sodium metabisulfite, a sulfite that may cause serious allergic type reactions (e.g, hives, itching, wheezing, anaphylaxis, severe asthma attack) in certain susceptible persons.

PRECAUTIONS (SEE WARNINGS)
Pregnancy Category C. Animal reproduction studies have not been conducted with topical hydroquinone. It is also not known whether hydroquinone can cause fetal harm when used topically on a pregnant woman or affect reproductive capacity. It is not known to what degree, it any, topical hydroquinone is absorbed systemically. Topical hydroquinone should be used by pregnant women only when clearly indicated.

Nursing mothers. It is not known whether topical hydroquinone is absorbed or excreted in human milk. Caution is advised when topical hydroquinone is used by a nursing mother.

Pediatric usage. Safety and effectiveness in pediatric patients below the age of 12 years have not been established.

ADVERSE REACTIONS
No systemic adverse reactions have been reported. Occasional hypersensitivity (localized contact dermatitis) may occur, in which case the medication should be discontinued and the physician notified immediately.

DOSAGE AND ADMINISTRATION
Solaquin Forte 4% Cream and Solaquin Forte 4% Gel should be applied to the affected area and rubbed in well twice daily or as directed by a physician.

Eldopaque Forte 4% Cream should be applied to the affected area twice daily or as directed by a physician. Do not rub in.

Eldoquin Forte 4% Cream should be applied to the affected area and rubbed in well twice daily or as directed by a physician. During the day, an effective broad spectrum sunscreen should be used and unnecessary solar exposure avoided, or protective clothing should be worn to cover bleached skin in order to prevent repigmentation from occurring.

OVERDOSAGE
There have been no systematic reactions from the use of topical hydroquinone. However, treatment should be limited to relatively small areas of the body at one time since some patients experience a transient skin reddening and a mild burning sensation which does not preclude treatment.

Store at 25C; excursion permitted to 15C-30C.

Do not use beyond the expiry date stated on the container.

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