cream 0.1% w/w
Description: White cream containing 0.17% of gentamicin sulphate
(equivalent to 0.1% of gentamicin) with methyl paraben 0.16% & propyl
paraben 0.03% as preservatives.
Action: Gentamicin sulphate is a broad spectrum aminoglycoside
antibiotic which is bactericidal. It acts directly on the bacterial
ribosome, where they inhibit protein synthesis and decrease the fidelity of
translation of the genetic code. It is effective against many strains of
gram-negative bacteria and staphylococcus aureus.
Pharmacology: Gentamicin sulphate is a bactericidal antibiotic
which is active against a wide variety of pathogenic gram-positive and
gram-negative bacteria. When applied topically to large areas of denuded
body surface as the case of burn patients, plasma concentrations can reach 1
mcg/ml, and 2% to 5% of the drug used may appear in the urine.
Indications: Treatment of impetigo, erythyma and other localised
primary bacterial skin infection with a Gram-negative component and also for
secondary bacterial infections complicating other pre-existing dermatoses.
Contraindication: Hypersensitivity to gentamicin sulphate or any
component in the base.
Adverse effect: Ototoxicity and nephrotoxicity has been reported
often in the topical treatment of severe burns with gentamicin.
Hypersensitivity reactions have been reported after local use.
Precautions/Warning: Discontinue use if hypersensitivity or
irritation, occurs. Prolong use of a preparation containing an antibiotic
may result in overgrowth of non susceptible organisms including fungi. If
this occurs, discotinue use and institute appropriate therapy. Not suitable
for ophthalmic use.
Recommended Dosage: Apply a small amount to the lesion three to
four times daily.
Use of topical gentamicin preparation in closed hospital settings is
Packing: Plastic jar of 450g and aluminium tubes of 15g.
Storage: Keep container well closed. Protect from strong light.
Store below 30oC. For external use only. Keep out of reach of
Recommended Shelf-life: 3 years.