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Gentamicin creamGentamicin cream 0.1% w/w

Description: White cream containing 0.17% of gentamicin sulphate (equivalent to 0.1% of gentamicin) with methyl paraben 0.16% & propyl paraben 0.03% as preservatives.

Action: Gentamicin sulphate is a broad spectrum aminoglycoside antibiotic which is bactericidal. It acts directly on the bacterial ribosome, where they inhibit protein synthesis and decrease the fidelity of translation of the genetic code. It is effective against many strains of gram-negative bacteria and staphylococcus aureus.

Pharmacology: Gentamicin sulphate is a bactericidal antibiotic which is active against a wide variety of pathogenic gram-positive and gram-negative bacteria. When applied topically to large areas of denuded body surface as the case of burn patients, plasma concentrations can reach 1 mcg/ml, and 2% to 5% of the drug used may appear in the urine.

Indications: Treatment of impetigo, erythyma and other localised primary bacterial skin infection with a Gram-negative component and also for secondary bacterial infections complicating other pre-existing dermatoses.

Contraindication: Hypersensitivity to gentamicin sulphate or any component in the base.

Adverse effect: Ototoxicity and nephrotoxicity has been reported often in the topical treatment of severe burns with gentamicin. Hypersensitivity reactions have been reported after local use.

Precautions/Warning: Discontinue use if hypersensitivity or irritation, occurs. Prolong use of a preparation containing an antibiotic may result in overgrowth of non susceptible organisms including fungi. If this occurs, discotinue use and institute appropriate therapy. Not suitable for ophthalmic use.

Recommended Dosage: Apply a small amount to the lesion three to four times daily.

Use of topical gentamicin preparation in closed hospital settings is actively discouraged.

Packing: Plastic jar of 450g and aluminium tubes of 15g.

Storage: Keep container well closed. Protect from strong light. Store below 30oC. For external use only. Keep out of reach of children.

Recommended Shelf-life: 3 years.

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