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Hydrochlorzide-25

Hydrochlorzide-50

COMPOSITION
Hydrochlorzide-25 Tablet: Each tablet contains Hydrochlorothiazide 25mg.
Hydrochlorzide-50 Tablet: Each tablet contains Hydrochlorothiazide 50mg.

PROPERTIES
Hydrochlorothiazide is a diuretic which acts by reducing resorption of electrolytes from renal tubules, thereby increasing excretion of sodium and chloride ions and along with these, water.

INDICATIONS
Hydrochlorzide is indicated for the treatment of oedema and hypertension.

DOSAGE AND ADMINISTRATION
To be administered orally.
ADULTS
Oedema : Usually, 25mg to 100mg once or twice daily or intermittently to a maximum of 200mg daily.

Hypertension : 25mg to 50mg daily; either alone or in conjunction with other antihypertensive agents, to a maximum of 100mg daily.

CHILDREN
Usually 2.5mg per kg body weight a day, given in two doses.

CONTRAINDICATIONS
Anuria, known hypersensitivity to this product or to other sulphonamides-derived drugs.

PRECAUTIONS
Patients should be carefully monitored for signs of fluid and electrolyte imbalance (hyponatraemia; hypochloraemic alkalosis; hypokalaemia and hypomagnesaemia).

Use with caution in impaired renal or hepatic function and diabetes mellitus.

It may precipitate attacks of gout in susceptible patients. The possibility of exacerbation or activation of systemic lupus erythematoses has been reported.

Use in pregnancy: use of Thiazides when pregnancy is present or suspected requires that the benefits of the drug be weighed against possible hazards to the foetus.

Use in breast-feeding mothers: Thiazides appear in breast milk. If use of the drug is deemed essential, the patient should stop breast feeding.

DRUG INTERACTIONS
Hydrochlorothiazide when given concurrently with alcohol, barbiturates or narcotics may cause potentiation of orthostatic hypotension. Dosage adjustment may be required if antidiabetic drug (oral agents and insulin) is given concurrently with thiazide diuretics.

Potentiation may occur with other antihypertensive drugs.

With corticosteroids and ACTH, intensified electrolyte depletion, particularly hypokalemia may occur.

Lithium should generally not be given with diuretics.

SIDE EFFECTS
Side effects of the gastrointestinal system are anorexia, gastric irritation, nausea, vomiting, cramps, diarrhoea, constipation, jaundice, pancreatitis and salivary gland inflammation.

Effects on central nervous system include dizziness, vertigo, paraesthesiae, headache and yellow vision. Other side effects include hypotension, impotence, hyperglycaemia, glycosuria, hyperuricaemia, electrolyte imbalance, leucopenia, agranulocytosis, thrombocytopenia, aplastic and haemolytic anaemia, hypersensitivity, purpura, photosensitivity, rash and urticaria.

OVERDOSAGE AND TREATMENT
In cases of overdosage and poisoning, hospital admission is strongly advised. Symptoms include severe forms of side effects. Treatment is symptomatic.

SHELF-LIFE
The expiry date is indicated on the packaging.

PRESENTATION
Hydrochlorzide-25 Tablet : Light orange, round tablets in blister pack of 30's.
Hydrochlorzide-50 Tablet : Dark orange, round tablets in blister pack of 30's and 100's.

STORAGE
Store below 30'C.

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