Hydrochlorzide-25 Tablet: Each tablet contains Hydrochlorothiazide 25mg.
Hydrochlorzide-50 Tablet: Each tablet contains Hydrochlorothiazide 50mg.
Hydrochlorothiazide is a diuretic which acts by reducing resorption of
electrolytes from renal tubules, thereby increasing excretion of sodium and
chloride ions and along with these, water.
Hydrochlorzide is indicated for the treatment of oedema and hypertension.
DOSAGE AND ADMINISTRATION
To be administered orally.
Oedema : Usually, 25mg to 100mg once or twice daily or intermittently to a
maximum of 200mg daily.
Hypertension : 25mg to 50mg daily; either alone or in conjunction with
other antihypertensive agents, to a maximum of 100mg daily.
Usually 2.5mg per kg body weight a day, given in two doses.
Anuria, known hypersensitivity to this product or to other sulphonamides-derived
Patients should be carefully monitored for signs of fluid and electrolyte
imbalance (hyponatraemia; hypochloraemic alkalosis; hypokalaemia and
Use with caution in impaired renal or hepatic function and diabetes
It may precipitate attacks of gout in susceptible patients. The
possibility of exacerbation or activation of systemic lupus erythematoses
has been reported.
Use in pregnancy: use of Thiazides when pregnancy is present or suspected
requires that the benefits of the drug be weighed against possible hazards
to the foetus.
Use in breast-feeding mothers: Thiazides appear in breast milk. If use of
the drug is deemed essential, the patient should stop breast feeding.
Hydrochlorothiazide when given concurrently with alcohol, barbiturates or
narcotics may cause potentiation of orthostatic hypotension. Dosage
adjustment may be required if antidiabetic drug (oral agents and insulin) is
given concurrently with thiazide diuretics.
Potentiation may occur with other antihypertensive drugs.
With corticosteroids and ACTH, intensified electrolyte depletion,
particularly hypokalemia may occur.
Lithium should generally not be given with diuretics.
Side effects of the gastrointestinal system are anorexia, gastric
irritation, nausea, vomiting, cramps, diarrhoea, constipation, jaundice,
pancreatitis and salivary gland inflammation.
Effects on central nervous system include dizziness, vertigo,
paraesthesiae, headache and yellow vision. Other side effects include
hypotension, impotence, hyperglycaemia, glycosuria, hyperuricaemia,
electrolyte imbalance, leucopenia, agranulocytosis, thrombocytopenia,
aplastic and haemolytic anaemia, hypersensitivity, purpura,
photosensitivity, rash and urticaria.
OVERDOSAGE AND TREATMENT
In cases of overdosage and poisoning, hospital admission is strongly
advised. Symptoms include severe forms of side effects. Treatment is
The expiry date is indicated on the packaging.
Hydrochlorzide-25 Tablet : Light orange, round tablets in blister pack of
Hydrochlorzide-50 Tablet : Dark orange, round tablets in blister pack of
30's and 100's.
Store below 30'C.