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Heparin
Contents
Heparin sodium
Indications
Prophylaxis & treatment of venous thrombosis & pulmonary embolism. Treatment of
myocardial infarction & arterial embolism. For prevention of clotting in arterial & heart surgery & prevention of cerebral thrombosis. As an anticoagulant in blood transfusions, extracorporal circulation, dialysis & for lab purposes.
Dosage
Hemodialysis: 7500-12,000 iu; IV admin 5000-10,000 iu 4 hourly.
SC admin 10,000 iu 8 hourly.
Low-dose heparin prophylaxis: 5000 iu SC 2-6 hourly pre-operative & 8-12 hourly post-operative
for 10-14 days or until the patient is mobile.
Contraindications
Hemorrhagic diseases, thrombocytopenia, hemophilia; subacute bacterial endocarditis; peptic ulcer; severe hypertension; patient who has recently undergone surgery at site where hemorrhage is a special risk; advanced renal or hepatic disease, jaundice.
Special Precautions
Pregnancy, elderly. Increased resistance is frequently encountered in thrombosis, thrombophlebitis infected with thrombotic tendencies, cancer, post-surgical patients.
Adverse Reactions
Transient alopecia, diarrhea; osteoporosis with spontaneous fractures. Occasionally, febrile or allergic reactions.
Drug Interactions
Drugs that interfere with platelet-aggregation reactions may induce bleeding. Digitalis, tetracycline, nicotine or antihistamine may partially counteract the anticoagulant action.
Presentation/Packing
Vial 5000 iu x 5 mL x 5's.
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