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HISTAC EVT

 

Contents

Ranitidine HCI

 

Indications

150 mg/300 mg tab Duodenal ulcer & benign gastric ulcer; prevention of NSAID associated duodenal ulcers. Treatment of post-op ulcer, Zollinger-Ellison syndrone & oesophageal reflux disease, & conditions where reduction of gastric secretion & acid output is desirable.

 

EVT tab Duodenal & gastric ulcer, Zollinger-Ellison syndrome, treatment adjunct in RA for relief of GI symptoms associated with NSAIDs, reflux oesophagitis, stress ulcers, short-bowel (anastomosis) syndrome, prophylaxis of GI haemorrhage from stress ulceration in seriously ill patients, prophylaxis of recurrent haemorrhage in patients with bleeding peptic ulcers & before GA in patients at risk of acid aspiration (Mendelson's syndrome), especially obstetric patients during labour, hypersecretory states associated with systemic mastocytosis or basophilic leukemia with hyperhistaminemia.

 

Dosage

150 mg/300 mg tab Adult 150 mg bd.

Duodenal ulcer, gastric ulcer, oesophageal reflux Single bedtime dose of 300 mg. Maintenance: 150 mg at bedtime or for oesophageal reflux disease 150 mg bd or 300 mg at bedtime for 8-12 week.

Severe oesophagitis 150 mg qds for up to 12 week.

Zollinger-Ellison syndrome 150 mg tds. Max: 6 g/day.

Chronic episodic dyspepsia 150 mg bd for up to 6 week.

Patients at risk of acid aspiration syndrome 150 mg 2 hr before induction of general anaesthetic & also 150 mg the previous evening.

 

EVT tab

Duodenal/gastric ulcer 150 mg bd for at least 4 week. Maintenance: 150 mg nocte.

Prophylaxis against duodenal ulceration 150 mg bd during therapy with NSAIDs.

GERD 150 mg bd for max 8 week.

Zollinger-Ellison syndrome Initially 150 mg bd-tds. max: 6 g daily.

Prophylaxis of GI haemorrhage from stress ulceration in seriously ill patients, prophylaxis of recurrent haemorrhage in patients with bleeding peptic ulcers 150 mg bd.

 

Special Precautions

Severe cirrhosis  severe renal impairment, hepatic impairment. Pregnancy & lactation.

 

Adverse Reactions

Hepatitis with or without jaundice. Acute pancreatitis. Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia. Bradycardia & AV block. Headache, dizziness, rare cases of reversible mental confusion, depression & hallucinations. Rash, arthralgia & myalgia, gynaecomastia.

 

Drug Interactions

Phenytoin, warfarin, theophylline, nifedipine & alcohol. Antacids, procainamide.

 

Presentation/Packing

Tab 150 mg x 10 x 10's. 300 mg x 5 x 10's.

EVT effervescent tab ( Coolmint flavour) 150 mg x 10's.

 

US FDA Preg Cat, : B

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