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Horamine


Description

Horamine Tablet : round, yellow uncoated tablet, shallow convex faces, "HD" embossed and scored on the same face.

Horamine Syrup : Red, raspberry flavoured viscous liquid

 

Composition
Horamine Tablet : Per Tablet - Chlorpheniramine Maleate 4 mg

Horamine Syrup : Per 5 ml - Chlorpheniramine Maleate 4 mg


Actions and Pharmacology
Chlorpheniramine acts by competing with histamine for H1-receptor sites on effector cells, thus preventing responses mediated by histamine. Its antimuscarinic actions will provide a drying effect on the nasal mucosa.

 

It is readily absorbed after oral administration, metabolised in the liver and excreted mainly in the urine.


Indications
For symptomatic treatment of:

Allergic or vasomotor rhinitis, hay fever, urticaria, angioneurotic oedema, sensitivity reactions and other itching skin conditions including pruritus ani, pruritus vulvae, pruritus of drug rashes, contact dermatitis and insect bites.

 

Contraindications

- Avoid in patients known to be hypersensitive to antihistamines.

- Use is not recommended in nursing mothers and in children below 6 years of age.

 

Precautions

- This medication may cause drowsiness in some patients. Caution when driving or operating machinery. Avoid alcoholic beverages.

- Safety for use in pregnancy has not been established.


Main Side/Adverse Effects

Drowsiness; dryness of mouth, nose, and throat; gastrointestinal disturbances.

 

Drug Interactions

- Co-administration of alcohol, other CNS depressants, tricyclic antidepressants or atropine may potentiate the effects of either these medications or chlorpheniramine.

- Concurrent use with monoamine oxidase (MAO) inhibitors may prolong andintensify the antimuscarinic effects of chlorpheniramine.

Overdosage

Clinical features: Drowsiness, staggering gait, hallucinations, convulsions, respiratory depression, coma.

 

Treat overdosage by giving activated charcoal to delay absorption of ingested drug and then remove by airway - protected gastric lavage followed by catharsis. Control convulsions, if any, by giving IV 0.1 mg/kg diazepam.

 

Dosage and Administration

Adults: Oral, 4 mg every four to six hours as needed, not exceeding 24 mg daily.

Children 6 to 12 years : Oral, 2 mg three or four times daily as needed, not exceeding 12 mg a day.

 

Shelf Life

3 years from the date of manufacture.

 

Storage

Store below 25C. Protect from moisture

 

Presentation/Packing

Tablet 4 mg x 1000's, blister of 10 x 10's

Syrup 4 mg/5ml x 3.6L, 100ml, 60ml

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