Horamine Tablet : round, yellow
uncoated tablet, shallow convex faces, "HD" embossed and scored on the same
Horamine Syrup : Red, raspberry
flavoured viscous liquid
Horamine Tablet : Per Tablet - Chlorpheniramine Maleate 4 mg
Horamine Syrup : Per 5 ml -
Chlorpheniramine Maleate 4 mg
Actions and Pharmacology
Chlorpheniramine acts by competing with histamine for H1-receptor sites on
effector cells, thus preventing responses mediated by histamine. Its
antimuscarinic actions will provide a drying effect on the nasal mucosa.
It is readily absorbed after oral
administration, metabolised in the liver and excreted mainly in the urine.
For symptomatic treatment of:
Allergic or vasomotor rhinitis,
hay fever, urticaria, angioneurotic oedema, sensitivity reactions and other
itching skin conditions including pruritus ani, pruritus vulvae, pruritus of
drug rashes, contact dermatitis and insect bites.
- Avoid in patients known to be
hypersensitive to antihistamines.
- Use is not recommended in
nursing mothers and in children below 6 years of age.
- This medication may cause
drowsiness in some patients. Caution when driving or operating machinery.
Avoid alcoholic beverages.
- Safety for use in pregnancy has
not been established.
Main Side/Adverse Effects
Drowsiness; dryness of mouth,
nose, and throat; gastrointestinal disturbances.
- Co-administration of alcohol,
other CNS depressants, tricyclic antidepressants or atropine may potentiate
the effects of either these medications or chlorpheniramine.
- Concurrent use with monoamine
oxidase (MAO) inhibitors may prolong andintensify the antimuscarinic effects
Clinical features: Drowsiness,
staggering gait, hallucinations, convulsions, respiratory depression, coma.
Treat overdosage by giving
activated charcoal to delay absorption of ingested drug and then remove by
airway - protected gastric lavage followed by catharsis. Control
convulsions, if any, by giving IV 0.1 mg/kg diazepam.
Dosage and Administration
Adults: Oral, 4 mg every four to
six hours as needed, not exceeding 24 mg daily.
Children 6 to 12 years : Oral, 2
mg three or four times daily as needed, not exceeding 12 mg a day.
3 years from the date of
Store below 25°C. Protect from
Tablet 4 mg x 1000's, blister of
10 x 10's
Syrup 4 mg/5ml x 3.6L, 100ml,