Yellow, round and flat tablets, 8mm diameter with score-line and without
Hydrochlorothiazide BP 50mg/tablet.
Hydrochlorothiazide is a diuretic which reduces the reabsorption of
electrolytes from renal tubules, thereby increasing the excretion of sodium
and chloride ions, and consequently of water. It also has a slight lowering
effect on the blood pressure and it enhances the effects of other
Hydrochlorothiazide is absorbed rapidly from gastrointestinal tract with a
bioavailability of about 65 to 75%. It excreted mainly unchanged in urine
and has a terminal half-life of 6 to 15 hours.
For oedema and hypertension.
Adults: For hypertension: 25 to 100mg daily in single or divided doses. For
oedema: Initially: 50 to 100mg 1 to 2 times daily; maintenance: 25-50mg on
Skip rashes, thrombocytopenia, thirst, epigastric pain, anorexia,
constipation, gastric irritation, nausea, vomiting, diarrhoea, dizziness,
headache, weakness, photosensitivity, postural hypotension, impotence and
Anuria; patients receiving lithium therapy. Patients hypersensitive to
May cause hypokalaemia, aggravate diabetes and gout. Caution in patients
with renal or hepatic impairment.
It may enhance the potassium depleting action of corticosteroids or enhance
the neuromuscular blocking action of non-depolarising muscle relaxants. Its
hypokalaemia effect can increase toxicity of cardiac glycosides.
USE IN PREGNANCY AND LACTATION
Hydrochlorothiazide crosses placental barrier and is excreted in breast
milk. It should not be used in pregnant and lactating women unless the
potential advantage justifies the possible risk to the foetus.
OVERDOSAGE AND TREATMENT
Common symptoms of overdosage are those caused by electrolyte depletion ( hypokalemia,
hyponatremia, hypochloremia ) and dehydration resulting from excessive
diuresis. Symptomatic treatment should be given and mainly on fluid and
electrolyte replacement. For recent ingestion gastric lavage should be
50mg tablets x 1000's bulk pack, blister pack of 10 x 10 x 10's.
EXPIRY PERIOD AND STORAGE
Do not use after the expiry date stated on the label.
Store below 30°C.