Supplementary therapy in moderate & sever hypertension.
Malignant hypertension in particular, pre-eclampsia & eclampsia associate
with toxaemia of pregnancy, pulmonary edema in cases of hypertensive heart failure to afford rapid symptoms relief from the cardiovascular effects of thyrotoxicosis.
Initially 10 mg once daily, raised later if required up to 25-50 daily.
Hypertension 1-2 ampoules
Rapid reduction in blood pressure 1 mg/mins
Phaeochromocytoma; prior treatment with MAO
inhibitors; heart failure not caused by hypertension.
Coronary or cerebral arteriosclerosis; history of
gastrointestinal ulceration; renal impairment; asthma; fever; road users. Withdraw prior to surgery. Pregnancy, lactation.
Mild central nervous system (CNS) disturbances, postural hypotension; diarrhea, parotid gland swelling; asthma; fluid retention. Occasionally, bradycardia, depression. Prolonged use, heart failure; sick sinus syndrome. Disturbances of potency.
Combination with antiarrythmics may cause sinus bradycardia. Hypotensive effect potentiated by reserpine, methyldopa, minoxidil & other vasodilators, cal antagonists, β-blockers, ACE inhibitors, alcohol. Tricyclic antidepressants, pizotifen, chlorpromazine, sypathomimetics, Oral
contraceptives antagonize hypotensive effect. Ismelin potentiates hypoglycemic effect of insulin & oral antidiabetics.
Tab 10 mg x 200's
Ampoules 10 mg/mL x 1's.