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Ismelin

 

Contents:

Guanethidine sulfate

 

Indications:

Tab

Supplementary therapy in moderate & sever hypertension.

Injection

Malignant hypertension in particular, pre-eclampsia & eclampsia associate with toxaemia of pregnancy, pulmonary edema in cases of hypertensive heart failure to afford rapid symptoms relief from the cardiovascular effects of thyrotoxicosis.

 

Dosage:

Tab

Initially 10 mg once daily, raised later if required up to 25-50 daily.

Injection

Hypertension 1-2 ampoules intra-muscular.

Rapid reduction in blood pressure 1 mg/mins intravenous infusion.

 

Contraindications:

Phaeochromocytoma; prior treatment with MAO inhibitors; heart failure not caused by hypertension.

 

Special Precautions:

Coronary or cerebral arteriosclerosis; history of gastrointestinal ulceration; renal impairment; asthma; fever; road users. Withdraw prior to surgery. Pregnancy, lactation.

 

Adverse Reactions:

Mild central nervous system (CNS) disturbances, postural hypotension; diarrhea, parotid gland swelling; asthma; fluid retention. Occasionally, bradycardia, depression. Prolonged use, heart failure; sick sinus syndrome. Disturbances of potency.

 

Drug interactions:

Combination with antiarrythmics may cause sinus bradycardia. Hypotensive effect potentiated by reserpine, methyldopa, minoxidil & other vasodilators, cal antagonists, β-blockers, ACE inhibitors, alcohol. Tricyclic antidepressants, pizotifen, chlorpromazine, sypathomimetics, Oral contraceptives antagonize hypotensive effect. Ismelin potentiates hypoglycemic effect of insulin & oral antidiabetics.

 

Presentation/Packing:

Tab 10 mg x 200's

Ampoules 10 mg/mL x 1's.

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