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Ketosteril

 

Composition
1 film-coated tablet contains :

Calcium-3-methyl-2-oxo-valerate

(α-Ketoanalogue to isoleucine, Calcium salt)

67 mg

Calcium-4-methyl-2-oxo-valerate

(α-Ketoanalogue to Leucine, Calcium salt)

101 mg

Calcium-2-oxo-3-phenylpropionate

(α-Ketoanalogue to Phenylalanine, Calcium salt)

68 mg

Calcium-3-methyl-2-oxo-butyrate

(α-Ketoanalogue to Valine, Calcium salt)

86 mg

Calcium-DL-2-hydroxy-4-(methylthio)-butyrate

(α-Hydroxyanalogue to Methionine, Calcium salt)

59 mg

L-Lysine-acetate ( =^75 mg L-Lysine)

105 mg

L-Threonine

53 mg

L-Trytophan

23 mg

L-Histidine

38 mg

L-Tyrosine

30 mg

 

 

Total nitrogen content/tablet

36 mg

Calcium/tablet

1.25 mmol  =^0.05 g

 

Indications

Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of 40 g per day (for adults) and less; i.e. generally in patients with a glomerular filtration rate (GFR) between 5 and about 15 ml/minutes.

 

Contraindications
Hypercalcemia, disturbed amino acid metabolism.
Note: No experience has been made so far with the application in pregnancy and pediatry.

 

Side effects
Hypercalcemia may develop.
Notes: Monitor regularly the serum calcium level. Ensure the sufficient supply with calories.

 

Interactions with other drugs
The simultaneous administration of medicaments containing calcium (e. g. acetolyte) may lead to pathological increases of the serum calcium level or intensification. As the uremic symptoms improve under Ketosteril, a possible administration of aluminium hydroxide should be reduced. Pay attention to a reduction of serum phosphate.


In order not to interfere with absorption, do not take drugs together with Ketosteril that form sparingly soluble compounds with calcium (e.g. tetracylines).

 

Application and Dosage
For oral use.
If not otherwise prescribed, take 4 to 8 tablets three times a day during meals. Swallow whole.
This dosage applies to adults (70 kg/BW).

 

Duration of Application

Ketosteril tablets are given as long as the glomerular filtration rate is between 5 and about 15 ml/minute. Simultaneously food should contain 40 g/day protein or less (adults).

 

Precautions

Do not use Ketosteril tablets after expiry date. Keep out of the reach of children.

 

Presentation

Pack containing 100 film-coated tablets

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