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Lasix
Contents:
Frusemide
Indications:
Tab 40 mg/Retard Cap
Edema ( cardiac, hepatic, renal;
edema due to burns), Hypertension.
Tab 500 mg/IV 250 mg
Acute renal failure. Chronic
renal failure in the predialytic stage. Terminal renal failure. Nephrotic
syndrome. Only indicated in greatly reduced glomerular filtration.
Injection 20mg
Edema ( cardiac, hepatic, renal,
cerebral; oedema due to burns). Acute heart failure (pulmonary oedema).
Hypertensive crisis. Poisoning (forced diuresis). Reduced urinary output in
gestosis. Prior to treatment, fluid volume must be restored to normal.
Dosage:
Tab 40 mg
20-80 mg daily. Children 2 mg/kg
body weight. Max: 40 mg/day.
Retard Cap
30-60 mg daily. Children 2 mg/kg
body weight Max: 40 mg/day.
Tab 500 mg
Min: 250 mg. Max: 1.5 g/24 hour.
In exceptional cases, up to 2 g/24 hour.
Injection 20 mg
Min: 20 mg daily. Children 1
mg/kg body weight. Max: 20 mg/day.
Contraindications:
Acute renal failure with anuria,
hepatic coma, hypokalemia, hyponatremia, hypovolemia with or without
hypotension. Impaired renal or hepatic function.
Special Precautions:
Pregnancy & lactation;
electrolyte & fluid imbalance; Impaired micturition. Diabetes, gout.
Adverse Reactions:
Minor gastrointestinal upset;
calsium, potassium & sodium depletion, nephrocalcinosis in premature
infants; aggravation of metabolic alkalosis; diabetes.
Rarely
Anaphylactic shock, allergic
reactions, bone marrow depression; acute pancreatitis, auditory disorders.
Drug interactions:
Increased risk of ototoxicity
with aminoglycosides, cisplatin & nephrotoxicity with aminoglycosides,
cefaloridine. ACE inhibitors may cause marked fall in blood pressure.
Antagonism with indomethacin. Potentiation with salicylates, theophylline,
lithium & curare-type muscle relaxants. Hypokalemia may precipitate
digitalis toxicity.
Presentation/Packing:
Tab 40 mg x 250's. 500 mg x
100's.
SR cap 30 mg x 250's
Special ampoules 250 mg/25 mL x
5's
Ampoules 20 mg/2 mL x 25's.
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