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Lasix

 

Contents:

Frusemide

 

Indications:

Tab 40 mg/Retard Cap

Edema ( cardiac, hepatic, renal; edema due to burns), Hypertension.

 

Tab 500 mg/IV 250 mg

Acute renal failure. Chronic renal failure in the predialytic stage. Terminal renal failure. Nephrotic syndrome. Only indicated in greatly reduced glomerular filtration.

 

Injection 20mg

Edema ( cardiac, hepatic, renal, cerebral; oedema due to burns). Acute heart failure (pulmonary oedema). Hypertensive crisis. Poisoning (forced diuresis). Reduced urinary output in gestosis. Prior to treatment, fluid volume must be restored to normal.

 

Dosage:

Tab 40 mg

20-80 mg daily. Children 2 mg/kg body weight. Max: 40 mg/day.

Retard Cap

30-60 mg daily. Children 2 mg/kg body weight Max: 40 mg/day.

Tab 500 mg

Min: 250 mg. Max: 1.5 g/24 hour. In exceptional cases, up to 2 g/24 hour.

Injection 20 mg

Min: 20 mg daily. Children 1 mg/kg body weight. Max: 20 mg/day.

 

Contraindications:

Acute renal failure with anuria, hepatic coma, hypokalemia, hyponatremia, hypovolemia with or without hypotension. Impaired renal or hepatic function.

 

Special Precautions:

Pregnancy & lactation; electrolyte & fluid imbalance; Impaired micturition. Diabetes, gout.

 

Adverse Reactions:

Minor gastrointestinal upset; calsium, potassium & sodium depletion, nephrocalcinosis in premature infants; aggravation of metabolic alkalosis; diabetes.

Rarely

Anaphylactic shock, allergic reactions, bone marrow depression; acute pancreatitis, auditory disorders.

 

Drug interactions:

Increased risk of ototoxicity with aminoglycosides, cisplatin & nephrotoxicity with aminoglycosides, cefaloridine. ACE inhibitors may cause marked fall in blood pressure. Antagonism with indomethacin. Potentiation with salicylates, theophylline, lithium & curare-type muscle relaxants. Hypokalemia may precipitate digitalis toxicity.

 

Presentation/Packing:

Tab 40 mg x 250's. 500 mg x 100's.

SR cap 30 mg x 250's

Special ampoules 250 mg/25 mL x 5's

Ampoules 20 mg/2 mL x 25's.

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