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Leftose

 

Description
White, round, flat bevelled edge tablet, with embossed 'Wellchem' logo on one side, and plain on the other, 8 mm in diameter.


Composition
Each tablet contains Lysozyme Hydrochloride 30 mg.


Therapeutic Properties
Leftose 30mg Tablet is a preparation containing a purified Lysozyme Hydrochloride derived from egg white.


Lysozyme is a basic protein composed of 129 amino acids of 18 different types with a molecular weight of about 14,300. Lysozyme Hydrochloride occurs as a white, crystalline powder. It has no odour and has a
sweet taste. It is very soluble in water.


Lysozyme is widely distributed in tears, nasal discharge, saliva, etc. in the case of humans. It has been discovered to possess anti-inflammatory, tissue repairing, mucopuslysing, etc. Thus, Lysozyme which has various actions plays an important role in the living body as an enzyme responsible for the physiological protective mechanism.

 

Clinically, Lysozyme has been used in expectation of its anti-inflammatory, expectorant, etc. in many fields.


Pharmacokinetics
When Lysozyme was administered orally to rabbits, its blood concentration showed the highest level approximately 60 minutes after the administration, then gradually decreased. It has been confirmed, by the experiment on absorption through enteric tracts of rats, that this drug is absorbed via portal vein.


Indications
1) Chronic paranasal sinusitis.
2) Difficulty of expectoration caused by respiratory diseases.


Contraindications
Contraindicated in patients who have shown hypersensitivity to Lysozyme or patients whose family members have a history of allergic reactions to Lysozyme.

Side Effects / Adverse Reactions
1) Shock
Since Lysozyme may cause shock symptoms, patients taking Lysozyme should be observed closely. If pallor facial, coldness of limbs, blood pressure dropped, cyanosis or unconsciousness occurred, discontinue the administration and appropriate treatment should be given.
2) Hypersensitivity
May cause hypersensitivity reactions, such as eruption or redness. Discontinue the medication if these symptoms occur.
3) Digestive System
May cause diarrhea, anorexia, discomfort in the stomach, nausea or vomiting, and rarely cause stomatitis.


Dosage And Administration
1) Chronic paranasal sinusitis
2) Difficulty of expectoration that accompanies respiratory diseases.

Adults: Take 1 to 3 tablets 3 times a day.
 

Usage In Pregnancy
As safety of Lysozyme has not been established, use with caution in pregnant women or women suspected of being pregnant.


Drug Interactions
None known


Overdosage And Treatment
No cases of acute overdose have been reported with Lysozyme Hydrochloride tablets. The oral LD50 of Lysozyme Hydrochloride is greater than 20 g/kg in mice.


Incompatibilities
None known


Storage Conditions
Keep in tightly closed container, below 30C. Keep out of reach of children.


Shelf-life : 3 years


Pack Size
In blister pack of 10's x 50, packed in outerbox.

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