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Melleril

 

Contents

Thioridazine hydrochloride

 

Dosage

Anxiolytic & antidepressant

Adult 10-75 mg daily.

Children ( In addition : difficulties of concentration, behavioural disorders, hyperactivity, aggressiveness, sleep disturbances ) 0.5-2 mg/kg body weight daily in divided doses.

 

Neuroleptic

Hospitalised psychotics 100-600 mg.

Psychotic outpatients 50-300 mg.

Alcoholic patients during withdrawal 100-200 mg.

 

Severe neuroses

25-150 mg. Max : 800 mg daily.

 

Children ( Childhood schizophrenia, severe behavioural disorders in mental retardation, psychopathy ) 1-4 mg/kg body weight daily in divided doses.

 

Contraindications

Comatose states or severe central nervous system (CNS) depression; history of blood dyscrasias; severe cardiovascular (CV) disease.

 

Special Precautions

Narrow-angle glaucoma, prostatic hypertrophy, CV disease, impaired liver function; when driving a vehicle or operate machinery; regular blood counts during the 1st few month & immediately when symptoms suggestive of blood dyscrasia occur; anticonvulsant medication may need dosage adjustment; pregnancy & lactation.

 

Adverse Reactions

Sedation, vertigo, orthostatic hypotension, nasal stuffiness, dry mouth, disturbances of visual accomodation, urinary retention or incontinence, galactorrhea, menstrual irregularities, disturbances of ejaculation, skin rashes, photosensitivity, nausea, constipation, weight change, hyperthermia, jaundice. At high dose extraphyramidal symptom; very rarely neuroleptic malignant syndrome, tardive dyskinesia after prolonged treatment. ECG changes, rarely arrhythmia, sudden unexplained death. Pigmentary retinopathy ( with very high doses & long-term treatment).

 

Drug interactions

Alcohol, CNS depressants, antihistomine, anticholinergics quinidine; levodopa, anticonvulsants, adrenergic vasoconstrictors; MAO inhibitors, lithium, β-blockers, antacids, anti-diarrheal drugs.

 

Presentation/Packing

Tab 10 mg x 1000's. 25 mg x 1000's. 100 mg x 1000's

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