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metasone cream 0.1% Metasone Cream 0.1% w/w

 

Composition:
Each preparation contains mometasone furoate (Micronised) 1 mg/g.


Description:
A white to off white, smooth homogenous mass


Pharmacodynamic:
Mometasone furoate has anti-inflammatory and anti-psoriatic activity.

Pharmacokinetic:
Systemic absorption following topical application of mometasone furoate 0.1 % is minimal (approximately 0.4% of the applied dose), the majority of which is excreted within 72 hours following application.


Indication:
Relief of the inflammatory and pruritic manifestation of corticosteroid-responsive dermatoses such as psoriasis and atopic dermatitis.
 

Recommended dosage:
A thin film of Metasone Cream 0.1 % should be applied to the affected skin areas once daily until the lesion heals or for a duration of 3 weeks whichever is sooner.


Contraindication:
Contraindicated in facial rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritis, napkin eruption, bacterial (e.g. impetigo), viral (e.g. herpes simplex, herpes zoster and chickenpox) and fungal (e.g. candida or dermatophyte) infections, varicella, tuberculosis, syphilis or post-vaccine reactions. Metasone should not be used in patients who are sensitive to mometasone furoate or to other corticosteroids.

Warning and precaution:
If irritation or sensitisation develops with the use of Metasone, treatment should be withdrawn and appropriate therapy instituted. An appropriate antifungal or antibacterial agent should be instituted if an infection develops. If a favourable response does not occur promptly, the corticosteroid should be discontinued until the infection is adequately controlled. Any of the side effects that have been reported following systemic use of corticosteroids, including adrenal suppression, may also occur with topical corticosteroids, especially in infants and children. Systemic absorption of topical corticosteroids will be increased if extensive body surface areas are treated or if the occlusive technique is used. Metasone is not for ophthalmic use.


Drug interaction:
None known


Pregnancy and lactation:
There is inadequate evidence of safety in human pregnancy. Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development including cleft palate and intra-uterine growth retardation. Topical corticosteroids should be used during pregnancy only if the potential benefit justifies potential risk to the fetus. Drugs of this class should not be used on pregnant patients in large amounts or for prolonged periods of time. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Metasone should be administered to nursing mothers only after careful consideration of the benefit/risk relationship.

Side effects:
Local adverse reactions rarely reported include burning, folliculitis, acneiform reaction, pruritus, paresthesia, tingling/stinging, and signs of skin atrophy.


The following local adverse reactions have been reported infrequently with the use of other topical corticosteroids: Irritation, hypertrichosis, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infections, striae and miliaria.

Overdosage:
Not applicable


Storage:
Store in a dry place below 30C.

For external use only.
Keep out of reach of children.


Shelf life: 3 years

Presentation:
Aluminium tubes of 5g, 10g and 15g

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