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Norcolut

 

Composition
Each tablet contains 5 mg norethisterone

Indications
Premenstruation syndrome, postponement of menstruation, mastodynia, cycle disturbance involving the shortening of the secretory phase, dysfunctional uterine bleeding, hyperplasia glandularis cystica endometrii, endometriosis, adenomyosis. Prevention of lactation, ablactation. Dysfunctional disturbances in bleeding during the menopause.

Contraindication
Puberty, pregnancy, mammary and genital carcinoma. Especially if the drug has to be taken permanently, the following cases should be judged separately: cardiac and renal diseases, asthma bronchiale, epilepsy, predisposition for thrombosis, hepatitis, disturbances in liver function.

Dosage
In premenstrual syndrome, mastodynia, and irregular cycles daily 5 - 10 mg (1 - 2 tablets) from the 16 - 25 day of the cycle, possibly with oestrogen. In dysfunctional uterine bleeding, hyperplasia glandularis cystica endometrii (provided the functional nature of the bleeding was confirmed by a histological test within 6 months) : for 6 - 12 days daily 5 - 10 mg (1- 2 tablets).


To prevent any relapse daily 5- 10 mg (1-2 tablets) from the 16 to the 25 day of the cycle, in general combined with oestrogen. Endometriosis, adenomyosis: daily 5 mg (1 tablet) from the 5th to 25th day of the cycle for 6 months, or if taken continuously, it should be begun with 2.5 mg (half a tablet) daily from the 5th day of the cycle and to prevent intermenstrual bleedings the dose should be increased by half a tablet every 2 - 3 weeks for as long as 4 - 6 months.


Postponement of menstruation: In cases of too frequent menstrual bleeding, and in special circumstances (e.g. operations, travel, sports) the postponement of menstruation is possible.


Take 1 tablet of Norcolut three times daily for no longer than 10 to 14 days, starting 3 days before the expected onset of menstruation. A normal period should occur 2-3 days after the patient has stopped taking tablets.

 

To prevent lactation :

  During the 16 - 28 weeks   during the 28 - 36 weeks
  In interrupted pregnancy
Day 1 15 mg ( 3 tablets )   1 mg ( 3 tablets )
Days 2 - 3 10 mg ( 2 tablets )   10 mg ( 2 tablets )
Days 4 - 7 5 mg ( 1 tablet )   10 mg ( 2 tablets )


Ablactation: 20 - 20 mg (4 - 4 tablets) from the 1 - 3 day, 15 - 15 mg (3 - 3 tablets) from the 4 - 7 day, daily 10 - 10 mg (2 - 2 tablets) from the 8 - 10 day. In dysfunctional disturbances during the menopause: a daily dose of 5 mg (1 tablet) is recommended as a cure, for a longer period of time. Provided this therapy should be prove unsuccessful, it is necessary to complete same by daily 25 - 50 μg ethinyloestradiol (Mikrofollin tablet).

Side effects
Headache, nausea, vomiting, breast tension, gastrointestinal complaints, intermenstual bleeding, fluid retention, paraesthesia, a change in body weight, fatigability occurring rarely and generally ceasing during the later cycles.

Drug interaction
It should be administered with caution together with enzyme inducers (they may accelerate its metabolism).

Warnings
Malignancy should be excluded before Norcolut treatment. Oncological control is necessary before the administration.


Package
20 tablets

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