OsteSAMIN plus Chondroitin & MSM Powder
Each 5.8g sachet contains:
Glucosamine Sulphate Potassium Chloride
equiv. to Glucosamine Sulphate 1500mg
Chondroitin Sulphate Sodium 1200mg
equiv. to Chondroitin Sulphate 1078mg
MSM (Methylsulfonylmethane) 1000mg
Powder: A yellow powder with odour of orange flavour
Solution: A yellow haze solution with mild sweet and orange taste
Glucosamine plays a major role in the promotion and maintenance of the
structure and function of cartilage in the bone joint. Glucosamine
stimulates the biosynthesis of mucopolysaccharides which is the key
structural components of joint cartilage which are essential for proper
joint function. Glucosamine also increases synovial fluid production and
viscosity, giving better lubricant activity for the joints. Glucosamine
sulphate is well-absorbed after oral intake, and is distributed mainly to
bones and joint tissues.
Chondroitin sulfate is vital for the structure and function of articular
cartilage. Chondroitin sulfate is important component of aggrecan which is
found in articular cartilage. Aggrecan confers upon articular cartilage
shock-absorbing properties. It does this by providing cartilage with a
swelling pressure that is restrained by the tensile force of collagen
fibers. This balance confers upon articular cartilage the deformable
resilience vital to its function.
Methylsulfonylmethane (MSM) is an organic sulphur-containing compound. It
is an oxidation product of the organic solvent, dimethyl sulfoxide (DMSO).
DMSO has been used in the treatment of arthritis and connective tissue
injuries because cartilage has a high content of sulphur, and sulphur is
needed for the formation of connective tissue, MSM as a source of sulphur
could be useful in the management of conditions such as osteoarthritis and
joint injuries where there is degeneration or destruction of cartilage.
After oral administration, bioavailability is low due to first-pass hepatic
metabolism 26% The gastrointestinal absorption is close to 90%.
Glucosamine is not protein-bound, but rather incorporates into plasma
proteins (primarily globulins).
Volume of Distribution: 2.5 Liters
The first-pass effect in the liver in which more than 70% of glucosamine is
Renal Excretion, 10%
Part of a dose of glucosamine sulfate is eliminated as carbon dioxide via
After oral administration, the bioavailability is 15-24%. A 10% of absorbed
chondroitin sulphate appears in unmetabolized form and 90% as depolymerized
derivatives with lower molecular weight, as a result of first-pass effect
The distribution volume of chondroitin sulphate is relatively low. In
humans, it has shown to have affinity for joint tissues. At least 90% of
chondroitin sulphate dose is first metabolized by lysosomal sulfateses, and
after that it is depolymerized by hyaluronidases ie, 13-glucuronidases and
13-N-acetyl hexose amidases. Liver, kidneys and other organs are involved in
the depolymerization of chondroitin sulphate. Chondroitin sulphate remains
in the body for 5-15 hours.
Main part of chondroitin sulphate and its depolymerized derivatives are
eliminated via the kidneys.
Soft tissue distribution of radioactivity indicated a fairly homogeneous
distribution throughout the body with relatively lower concentrations in
skin and bone. Approximately 85.8% of the dose was recovered in the urine
after 120 hour where only 3% was found in the feces. No quantifiable levels
of radioactivity were found in any tissues after 120 hours, indicating
complete elimination of MSM. This indicates that MSM is rapidly absorbed,
well distributed, and completely excreted from the body.
Adjunctive therapy for osteoarthritis
ROUTE OF ADMINISTRATION:
Dosage: One sachet a day.
Direction for use:
Mix 1 sachet powder into a glass of water (approximately 200ml). Stir until
Sachets should be taken 15 minutes before meals.