Medical  Explorer

Custom Search

Drugs A to Z  :  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  R  S  T  U  V  W  X  Y  Z
Medicinal Ingredients : A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Beauty Products : A  B  C  D  E  F  G  I  M  N  O  P  R  S  T  V

Aging      Allergies     Alzheimer's      Arthritis    Asthma      Bacteria   new Cancer    Chickenpox     Colds     Constipation      Diabetes      Epilepsy     Fatigue     Fever     Genetics       Haemorrhoids       newHeadaches      Hepatitis    Immunity      Infection      Insomnia       Leprosy       Menopause      Obesity      Osteoporosis     Other Diseases    Pain      PMS     Parasites     Sinusitis     newStroke     Toxicology    Urology




Arthritis medications
Acupuncture
Alcohol
Patients
newGeneral Health
Medicinal food
Chinese medicine
Nutrients
Smoking
Vitamins
OTC Drugs
Health Products
Therapy
Symptom
Parasitology
 
 
OsteSAMIN plus Chondroitin & MSM Powder

Each 5.8g sachet contains:
Glucosamine Sulphate Potassium Chloride
equiv. to Glucosamine Sulphate 1500mg
Chondroitin Sulphate Sodium 1200mg
equiv. to Chondroitin Sulphate 1078mg
MSM (Methylsulfonylmethane) 1000mg

DESCRIPTION:
Powder: A yellow powder with odour of orange flavour
Solution: A yellow haze solution with mild sweet and orange taste

PHARMACODYNAMICS:
Glucosamine plays a major role in the promotion and maintenance of the structure and function of cartilage in the bone joint. Glucosamine stimulates the biosynthesis of mucopolysaccharides which is the key structural components of joint cartilage which are essential for proper joint function. Glucosamine also increases synovial fluid production and viscosity, giving better lubricant activity for the joints. Glucosamine sulphate is well-absorbed after oral intake, and is distributed mainly to bones and joint tissues.

Chondroitin sulfate is vital for the structure and function of articular cartilage. Chondroitin sulfate is important component of aggrecan which is found in articular cartilage. Aggrecan confers upon articular cartilage shock-absorbing properties. It does this by providing cartilage with a swelling pressure that is restrained by the tensile force of collagen fibers. This balance confers upon articular cartilage the deformable resilience vital to its function.

Methylsulfonylmethane (MSM) is an organic sulphur-containing compound. It is an oxidation product of the organic solvent, dimethyl sulfoxide (DMSO). DMSO has been used in the treatment of arthritis and connective tissue injuries because cartilage has a high content of sulphur, and sulphur is needed for the formation of connective tissue, MSM as a source of sulphur could be useful in the management of conditions such as osteoarthritis and joint injuries where there is degeneration or destruction of cartilage.

PHARMACOKINETICS

Glucosamine:
Absorption
After oral administration, bioavailability is low due to first-pass hepatic metabolism 26% The gastrointestinal absorption is close to 90%.

Distribution
Glucosamine is not protein-bound, but rather incorporates into plasma proteins (primarily globulins).
Volume of Distribution: 2.5 Liters

Metabolism
Liver, extensive
The first-pass effect in the liver in which more than 70% of glucosamine is metabolized.

Excretion
Renal Excretion, 10%
Feces, 11%
Part of a dose of glucosamine sulfate is eliminated as carbon dioxide via expired air.

Chondroitin sulphate:
Absorption
After oral administration, the bioavailability is 15-24%. A 10% of absorbed chondroitin sulphate appears in unmetabolized form and 90% as depolymerized derivatives with lower molecular weight, as a result of first-pass effect metabolism.

Distribution
The distribution volume of chondroitin sulphate is relatively low. In humans, it has shown to have affinity for joint tissues. At least 90% of chondroitin sulphate dose is first metabolized by lysosomal sulfateses, and after that it is depolymerized by hyaluronidases ie, 13-glucuronidases and 13-N-acetyl hexose amidases. Liver, kidneys and other organs are involved in the depolymerization of chondroitin sulphate. Chondroitin sulphate remains in the body for 5-15 hours.

Excretion
Main part of chondroitin sulphate and its depolymerized derivatives are eliminated via the kidneys.

Methylsulfonylmethane:
Soft tissue distribution of radioactivity indicated a fairly homogeneous distribution throughout the body with relatively lower concentrations in skin and bone. Approximately 85.8% of the dose was recovered in the urine after 120 hour where only 3% was found in the feces. No quantifiable levels of radioactivity were found in any tissues after 120 hours, indicating complete elimination of MSM. This indicates that MSM is rapidly absorbed, well distributed, and completely excreted from the body.

INDICATION:
Adjunctive therapy for osteoarthritis

ROUTE OF ADMINISTRATION:
Oral administration.

RECOMMENDED DOSE
Dosage: One sachet a day.
Direction for use:
Mix 1 sachet powder into a glass of water (approximately 200ml). Stir until dissolved.
Sachets should be taken 15 minutes before meals.

1   2

Abdomen
Blood
Bone
Breast
Ear

Eye

Face
Hair

Head

Heart
Kidney
Liver
Limbs
Lungs
newMind
Mouth
Muscles
Nails

Neck

newNerves
Nose

Skin

Teeth

Throat

Tongue
 
Health news
 
Cardiovascular Guide
 
Natural Remedies
 
Treatment of Cancer
 
Women's Health
 
Irritable bowel syndrome
 
Common Childhood Illnesses
 
Prescribed Drugs
 
 

     
         
     

 

Disclaimer