Prophylaxis & treatment of
pulmonary embolism & venous thrombosis.
Initially 30-50 mg. Maintenance:
Bleeding or tendency to bleed,
blood dyscrasias, purpura, open ulcerative, traumatic & surgical wounds,
ulceration of the gastrointestinal tract, visceral carcinoma, diverticulitis,
colitis, subacute bacterial endocarditis, imminent abortion, recent eye,
brain or spinal cord surgery, regional & lumbar block anesthesia, severe
hypertension, severe hepatic or renal disease & when there is continuous
tubal drainage of the gastrointestinal or urinary tract; pregnancy.
Vitamin K deficiency,
Infrequent, hemorrhage; alopecia,
fever, gastrointestinal disorders, hypersensitivity reactions; 'purple toes.
Occasionally skin necrosis ( obese elderly patients ).
Activity potentiated by
cimetidine, clofibrate, co-trimoxazole, erythromycin, quinidine,
phenylbutazone, sulfonamides, metronidazole. Drugs which may increases risk
of bleeding including aspirin, NSAIDs, dipyridamole, cefamandol, moxalactam.
Activity decreased by cholestyramine, barbiturates, carbamazepine,
griseofulvin, phenytoin, rifampicin.
Tab 3 mg x 100's. 5 mg x 500's.