ORFARIN

Contents:

Warfarin

Indications:

Prophylaxis & treatment of pulmonary embolism & venous thrombosis.

Dosage:

Initially 30-50 mg. Maintenance: 2-5 mg.

Contraindications:

Bleeding or tendency to bleed, blood dyscrasias, purpura, open ulcerative, traumatic & surgical wounds, ulceration of the gastrointestinal tract, visceral carcinoma, diverticulitis, colitis, subacute bacterial endocarditis, imminent abortion, recent eye, brain or spinal cord surgery, regional & lumbar block anesthesia, severe hypertension, severe hepatic or renal disease & when there is continuous tubal drainage of the gastrointestinal or urinary tract; pregnancy.

Special Precautions:

Elderly

Vitamin K deficiency, hyperthyroidism.

Adverse Reactions:

Infrequent, hemorrhage; alopecia, fever, gastrointestinal disorders, hypersensitivity reactions; 'purple toes. Occasionally skin necrosis ( obese elderly patients ).

Drug interactions:

Activity potentiated by cimetidine, clofibrate, co-trimoxazole, erythromycin, quinidine, phenylbutazone, sulfonamides, metronidazole. Drugs which may increases risk of bleeding including aspirin, NSAIDs, dipyridamole, cefamandol, moxalactam. Activity decreased by cholestyramine, barbiturates, carbamazepine, griseofulvin, phenytoin, rifampicin.

Presentation/Packing:

Tab 3 mg x 100's. 5 mg x 500's.