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Pocin-G Eye Drops


DESCRIPTION

A clear, sterile solution.

CONTENTS

Polymyxin B Sulphate B.P. ................... 5000i.u.

Neomycin Sulphate B.P. ......................  1700i.u.

Gramicidin U.S.P. ................................  0.025mg/ml

Preservative : Benzalkonium Chloride .... 0.01%


MECHANISMS OF ACTION
Neomycin Sulpahte

Neomycin is an aminoglycoside which is actively transported across the bacterial cell membrane where it binds to a specific receptor protein on the 30 S subunit of bacterial ribosomes. neomycin is bacteriocidal.

 

Polymyxin B Sulphate

Polymyxin B is bacteriocidal and active against Pseudomonas aeruginosa and other gram-negative bacteria.

 

Gramicidin

Gramicidin act as a cationic detergent.


DOSAGE
Antibacterial

1 drop, to the conjunctiva, every 15 to 30 minutes initially, the frequency being reduced gradually depending on patient response.

 

Other infections

1 drop, to the conjunctiva, 2 to 4 times a day (or more frequently if required) for 7 to 10 days.

 

Patient counselling Notes

Do not touch tip to any surface.

Discard unused portion after compliance to full therapy.


PHARMACOLOGY (summary of pharmacodynamic and pharmacominetics)

Neomycin and Polymyxin B may be absorbed following topical application to the eye if tissue damage is present. Gramicidin is not significantly absorbed.

 

TOXICOLOGY (BRIEF)

Problems involving reproduction, pregnancy and breast-feeding have not been documented in humans. No paediatric and geriatric specific problems have been reported to date.

INDICATIONS
Pocin G Eye Drops are used in the treatment and prevention of external bacterial infections of the eye including conjunctivitis, blepharitis, keratitis, corneal ulcers, styes, abrasions and lacerations. The antibacterial range of the antibiotics covers practically all bacteria likely to occur in the eye.

CONTRAINDICATIONS
Pocin G Eye Drops should not be used in patients with sensitivity to neomycin, polymyxin B and gramicidin.

 

SIDE EFFECTS / ADVERSE REACTIONS

Hypersensitivity reactions have been reported following application of Pocin G eye drops. Less frequently, burning or stinging of the eye occurs.

 

PRECAUTIONS / WARNINGS

Prolonged use may result in posterior subcapsular cataract formation and glaucoma with raised opticocular pressure. Perforation has been known to occur in patients with disease causing thinning of the cornea. Safety on intensive or prolonged use of topical steroids during pregnancy has not been substantiated. Extensive use may lead to systemic effects

 

PACKING / PACK SIZE

5ml and 10 ml.

 

STORAGE CONDITIONS

Keep container tightly closed.

Store in a dry place below 25C.

Protect from light and moisture.

Keep out of reach of children.

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