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Panadol C

       For Relief of Symptoms Relate to Cold

 

What is this for ?

For the temporary relief of sinus congestion and pain associated with allergies, rhinitis or the common cold.

 

What does it contain ?

White capsule-shaped caplet with flat edges with face marked Panadol C.

Each caplet contain : Pseudoephedrine Hydrochloride 30mg, Paracetamol 500mg

 

How to use ?

Adults and children over 12 years : 1 - 2 caplets, every 4 - 6 hours ( not more than 8 one day )

 

Pharmacology

Pseudoephedrine Hydrocholoride is readily and completely absorbed from the gastrointestinal tract. Elimination is enhanced and half life accordingly shorter in acid urine. Paracetamol absorption takes place mainly in the small intestine. Peak plasma concentrations are reaches to 1 hour after absorption. The plasma half life is 1 to 3 hours. Paracetamol is metabolized by microsomal enzyme system of the liver to glucuronide and sulphate conjugates, accounting for approximately 49% and 26% of ingested dose respectively.

 

Side Effects

Paracetamol : When taken as directed, Panadol is virtually free of side effects. Skin rash and other allergic reactions have been described rarely.

 

Pseudoephedrine : Pseudoephedrine may occasionally cause insomnia; urinary retention in male subjects where prostatic enlargement is present. A fixed drug eruption due to Pseudoephedrine, taking the form of erythematous nummular patches, has been reported but should be regarded as a rare occurrence.

 

Precaution

Panadol C should be administered with caution to patients with hepatic or renal dysfunction, severe hypertension, cardiac or peripheral vascular disease, hyperthyroidism, uncontrolled diabetes, prostatic enlargement, or on antidepressant therapy and other sympathomimetic agents such as decongestant, appetite stimulant and amphetamine-like psychostimulants. If you are pregnant or nursing a baby, please consult your doctor.

 

Drug Interaction

Concomitant use of Panadol C with other sympathomimetic agents such as decongestants, tricyclic antidepressants, appetite suppressants and amphetamine-like psychostimulants or with monoamine oxidase inhibitors, which interfere with the catabolism of sympathomimetic amines, may occasionally cause a rise in blood pressure.

 

Because of its Pseudoephedrine content, Panadol C may partially reverse the hypotensive active of drugs which interfere with sympathetic activity including bretylium, bethanidine, guanethidine, deprisoquine, methyldopa, alpha and beta adrenergic blocking agents. (Ref. USP DI VOL. 2, 1986)

 

Symptoms & Treatment For Overdosage & Antidote(s)

Symptoms :

Toxic symptoms include vomiting, abdominal pain, hypotension and sweating. The most serious adverse effect of acute overdosage of Paracetamol is a dose-dependent, potentially fatal hepatic necrosis. In adults, hepatotoxicity ma occur after ingestion of a single dose of 10 to 15 g (30 caplets) of Paracetamol; a dose of 25 g (50 caplets) or more is potentially fatal. Symptoms during the first 2 days of acute poisoning by Paracetamol do not reflect the potential seriousness of the intoxication. Major manifestations of liver failure such as jaundice, hypoglycemia and metabolic acidosis may take at least 3 days to develop.

 

Treatment :

In cases of overdosage,methods of reducing the absorption of ingested drug are important. Gastric lavage is essential even if several hours have elapsed. Prompt administration of 50g activated charcoal and 500ml iced mannitol 20% by mouth may reduce absorption. If the history suggests that 15g Paracetamol or more has been ingested, administer one of the following antidotes :

* Acetylcysteine 20% i.v. : Administer intravenously, 20% acetylcysteine (Parvolex, Glaxo) immediately without waiting for positive urine test or plasma level results : initial dose of 150mg/kg over 15 minutes, followed by continuous infusion of 50mg/kg in 500ml 5% glucose over 4 hours and 100mg/kg in 1L 5% glucose over 16 hours; or

 

Oral Methionine : 2.5g immediately followed by three further doses of 2.5g at four hourly intervals. For a 3 year old child, 1g methionine every four hours for four doses has been used; or

 

Oral Acetylcysteine 5% : 140 mg/kg as a loading dose, then 70mg/kg every 4 hours for a total of 17 maintenance doses. If more than ten hours have elapsed since the overdosage was taken, the antidote may be in ineffective.

 

Packsize

Blisters of 10's.

Box of 20 blisters of 10's.

 

How to store ?

Store at room temperature ( 15C - 30C )

 

Expiry

Do not use beyond the expiry date.

 

Warning

Patients should avoid alcohol while taking Panadol C. If symptoms persist, please consult your doctor.

 

This preparation contains Paracetamol. Do not take any other Paracetamol containing medicines at the same time. Keep out of reach of children.

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