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Panamol

 

  Each tablet contains: Description

PANAMOL TABLET 500 MG

Paracetamol BP 500 mg

Pink coloured tablet

PANAMOL TABLET 250 MG

Paracetamol BP 250 mg

Pink coloured tablet

Preservative

Sodium Benzoate BP 0.1 %

 

 

 

Each tablet contains:

 

PANAMOL CAPSULE 250 MG

Paracetamol BP 250 mg

Dark Blue coloured/

Blue coloured capsule

 

Each 5 ml contains:

 

PANAMOL SYRUP 250 MG / 5 ML

Paracetamol BP 250 mg

Red coloured syrup

PANAMOL SYRUP 120 MG / 5 ML

Paracetamol BP 120 mg

Orange coloured syrup

PANAMOL SUSPENSION 250 MG / 5 ML

Paracetamol BP 250 mg

Orange coloured suspension

Preservatives
Methyl Paraben BP 0.1 Propyl Paraben BP 0.01%
   

 

Mechanism of Action

Analgesic:
Paracetamol acts by inhibiting prostaglandin synthesis in the central nervous system and through a peripheral action by blocking pain impulse generation. The peripheral action may also he due to the inhibition of the synthesis or actions of other substances, which sensitize pain receptors to mechanical or chemical stimulation.


Anti-pyretic:
Paracetamol produces anti-pyresis by acting centrally on the hypothalamic heat-regulating center to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the hypothalamus.


Indication
Indicated for the relief of mild to moderate pain and to reduce fever.


Contra-Indication

Contra-indicated in nephropathy.


Paracetamol may interact with the following drugs:
Alcohol, hepatic anzyme inducing agents, hepatotoxic medications, anti-coagulants, coumarin or indandione derivatives, anti-inflammatory analgesics, non-steroidol anti-inflammatory analgesics, aspirin or other salicylates.


Warning / Precaution
The use of this medication should be carefully considered when the following medical problems exist: Alcoholism, hepatic disease, renal function impairment, pregnancy and cardiovascular disease.

This medication contains Paracetamol (Acetaminophen). Do not take any other paracetamol / acetaminophen containing medicines at the same time.

Adverse Effect
Those indicating need for medical attention includes bloody or cloudy urine, sudden decrease in amount of urine, skin rash, hives, itching, unexplained sore throat and fever, unusual bleeding or bruising, unusual tiredness or weakness and yellowing of eyes or skin.

 

Overdosage may cause hepatic necrosis and hypoglycemic coma. In adults, hepatotoxicity may occur after ingestion of a single dose of 10 - 15 gm.

 

Dosage

To be given every 4 - 6 hourly, up to 4 times a day:

Adult 0.5 - 1 gm, 4 -6 hourly
7 - 12 years 250 - 500 mg, 4 - 6 hourly
1 - 6 years 120 - 250 mg, 4 - 6 hourly
4 - 12 months 60 mg, 4 - 6 hourly


Symptoms and Treatment for Over-dosage

Symptoms
Acute : Gastrointestinal upset (diarrhea, loss of appetite, nausea, vomiting, stomach cramps or pain) and increased sweating.
Chronic : Hepatotoxicit (pain, tenderness and/ or swelling in upper abdominal area)

Treatment
It is recommended that acetylcysteine be administered as soon as possible after ingestion on an overdose is reported. Induction of vomiting or gastric lavage should be performed, followed by oral administration or activated charcoal. For patients with a plasma acetaminophen concentration greater than 120 ug/ml, hemodialysis, if possible, should be initiated within the first 12 hours.


Packing
Tablet

Plastic container of 30's and 100's
Blister-packs of 10 x 10's/Box

Capsule

Blister-packs of 10 x 10's/Box
Syrup / Suspension

Plastic bottle of 60 ml and 100 ml.

Pharmaceutical Precaution
Store below 30C in a dry place, protected from direct light.

Keep away from reach of children.

 

Expiry date
Tablet / Capsule : 3 years from date of manufacture.

Syrup / Suspension : 2 years from date of manufacture.

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