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PrednisolonePrednisolone

DESCRIPTION

Round, white uncoated tablet, shallow convex faces; "HD" embossed and scored on the same face.


ACTIONS AND PHARMACOLOGY

Prednisolone, a synthetic glucocorticoid, has both anti-inflammatory and immunosuppressant actions. It acts by inhibition of phagocytosis, leukocyte migration and capillary dilatation, and prevention or suppression of cell mediated (delayed hypersensitivity) immune reactions respectively.

It is readily absorbed orally, metabolised in the liver and excreted via the kidneys.

INDICATIONS

Prednisolone is used in the treatment of conditions where a routine systemic corticosteroid therapy is indicated. Its weaker sodium-retaining action usually makes it more suitable than cortisone in such conditions as rheumatoid arthritis, rheumatic fever, status asthmaticus and ulcerative colitis.

 

CONTRAINDICATION

Use is not recommended in nursing mothers, wherever possible.

 

PRECAUTIONS
Caution in patients with osteoporosis, peptic ulcer, psychoses, systemic fungal infections, diabetes mellitus, hypertension, myasthenia gravis, ocular herpes simplex, glaucoma, hypothyroidism, history of tuberculosis, renal and hepatic function impairment.
When medication is to be discontinued, dosage should be reduced gradually. Abrupt cessation of prolonged therapy may produce acute adrenal insufficiency.
Frequent monitoring of drug effect is required.
Caution in receiving vaccinations, other immunizations and skin test.
Children on prolonged therapy should be closely observed.

Safety for use in pregnancy has not been established.

 

MAIN SIDE / ADVERSE EFFECTS

Dyspepsia, peptic ulceration; long term use include Cushings syndrome, acne, osteoporosis, mental changes and endocrine imbalance.

 

DRUG INTERACTIONS:
Response to prednisolone may be reduced by co-administration of barbiturates, phenytoin or rifampicin.
Effects of oral anticoagulants or salicylates may be decreased when used concurrently with prednisolone.
Caution in patients receiving the following drug therapy Alcohol, anti-inflammatory medications, cardiac glycosides, ephedrine, heparin, hypoglycaemics.

OVERDOSE

Clinical features : Nausea and vomiting, hyperglycaemia, occasional gastrointestinal bleeding.

Treat overdose by symptomatic measures.

DOSAGE AND ADMINISTRATION:
Adults : Oral, 5 to 60 mg a day as a single dose or in divided doses, not exceeding 250mg daily.
Children : As directed by physician.

Note : The paediatric dosage is determined more by the severity of the condition and response of the patient than by age or body weight.

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