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Rytmonorm

 

Contents:
Propafenone hydrochloride

Indications:
Prophylaxis & treatment of ventricular & supraventricular extrasystoles, ventricular & supraventricular tachycardia & tachyarrhythmia, including Wolff-Parkinson-White syndrome.

Dosage:

Patients 70kg body weight

Initial & maintenance dose : 450-600 mg daily. An increase to 900 mg daily may be necessary.

 

Contraindications:

Manifest heart failure; cardiogenic shock ( except for shock induced by arrhythmia ); severe bradycardia; pre-existing high degree SA, atrio-ventricular & intraventricular disorders of impulse conduction; sick sinus syndrome; manifest disorders; of electrolyte balance; severe obstructive pulmonary disease; marked hypotension, myasthenia gravis.

Special precautions:
Impaired function of liver or kidneys; 1st trimester of pregnancy, lactation, elderly. May impair ability to drive or operate machinery.

Adverse reactions:
Occasionally, anorexia, sensation of repletion, nausea, vomiting, bitter taste, numbness of mouth.

Sporadically blurred vision; vertigo; allergic skin reactions; circulatory dysregulation in orthostasis. Rarely, fatigue, headache, psychic disorders, extraphyramidal symptoms; bradycardia, SA, AV or intraventricular blocks. Cholestasis. Risk of eliciting ventricular tachycardia or ventricular flutter fibrillation; Diminution of potency & drop in sperm count ( high dose); very rarely, fully reversible decrease of white cell, granulocyle & platelet counts; agranulocytosis.

Drug interactions:

Effect may be potentiated by local anesthetic, β-blockers, tricyclic antidepressants. May increase plasma level of propranolol, metoprolol, digoxin. Plasma concentration may rise when taken simultaneously with cimetidine. May enhance effect of anticoagulant.

 

Presentation/ Packing :

Film-coated tab 150 mg x 50's. 300 mg x 50's

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