Prophylaxis & treatment of ventricular & supraventricular extrasystoles,
ventricular & supraventricular tachycardia & tachyarrhythmia, including
Patients 70kg body weight
Initial & maintenance dose :
450-600 mg daily. An increase to 900 mg daily may be necessary.
Manifest heart failure;
cardiogenic shock ( except for shock induced by arrhythmia ); severe
bradycardia; pre-existing high degree SA, atrio-ventricular &
intraventricular disorders of impulse conduction; sick sinus syndrome;
manifest disorders; of electrolyte balance; severe obstructive pulmonary
disease; marked hypotension, myasthenia gravis.
Impaired function of liver or kidneys; 1st trimester of pregnancy, lactation,
elderly. May impair ability to drive or operate machinery.
Occasionally, anorexia, sensation of repletion, nausea, vomiting, bitter taste,
numbness of mouth.
Sporadically blurred vision; vertigo; allergic skin reactions;
circulatory dysregulation in orthostasis. Rarely, fatigue, headache, psychic
disorders, extraphyramidal symptoms; bradycardia, SA, AV or intraventricular
blocks. Cholestasis. Risk of eliciting ventricular tachycardia or
ventricular flutter fibrillation; Diminution of potency & drop in sperm
count ( high dose); very rarely, fully reversible decrease of white cell,
granulocyle & platelet counts; agranulocytosis.
Effect may be potentiated by
local anesthetic, β-blockers, tricyclic antidepressants. May increase
plasma level of propranolol, metoprolol, digoxin. Plasma concentration may
rise when taken simultaneously with cimetidine. May enhance effect of
Presentation/ Packing :
Film-coated tab 150 mg x
50's. 300 mg x 50's