White yellowish ointment.
Betamethasone dipropionate ( eq.
to betamethasone 0.05% ) ...... 0.065% w/w
It is used for
the relief of seborrheic dermatitis, ichthyosis vulgaris, psoriasis and
other inflammatory, corticosteroid-responsive dermatoses, hyperkeratotic and
dry, scaling skin conditions.
Betamethasone dipropionate is a
glucocorticoid applied topically in the management of various disorders in
which corticosteroids are indicated. It has marked antipruritic,
vasoconstrictor and anti-inflammatory activity.
Salicylic acid is a keratolytic
with bacteriostatic and fungicidal actions.
Betamethasone dipropionate is
well absorbed from the sites of local application, particularly under an
occlusive dressing or when the skin is broken. It may be absorbed to give
systemic effects. It is more slowly metabolized in the skin and this tend to
be systemically absorbed in a greater extent. Salicylic acid is also rapidly
absorbed through the skin.
It is contraindicated in patients
hypersensitive to salicylic acid and betamethasone dipropionate or any
Steroids applied topically over
large areas, particularly when the skin is broken, with or without occlusive
dressings may result in systemic effects. Therefore, suitable precautions
should be taken. Special precautions have to be observed when used on
infants and children as it may cause growth retardation on prolonged use.
Therefore, avoid prolonged use in children and on the face.
It use should be discontinued if
excessive dryness, irritation or sensitization of the skin occurs.
Avoid contact with the eyes and
Use in pregnancy and lactation
Risk benefits should be
considered when using on pregnant or lactating mothers although safety of
use has not been established.
When applied topically,
particularly to large areas or when the skin is broken or under occlusive
dressings, betamethasone dipropionate may be absorbed in sufficient amounts
to cause systemic effects, eg. burning, itching irritation, acneiform
eruptions, hypopigmentation, perioral dermatitis, allergic contact
dermatitis, hypertrichosis and folliculitis.
Dosage and administration
Apply over affected skin twice
Treatment of over dosage
Symptoms: excessive or
prolonged use of topical corticosteroids can suppress pituitary-adrenal
function, resulting in secondary adrenal insufficiency, and produce
manifestations of hypercoticism, including Cushing's disease. Prolonged use
of salicylic acid causes salicylism.
treatment is applied. Slow withdrawal of steroids in advised and treat
electrolyte imbalance, if any. For salicylism, sodium bicarbonate is given
orally to alkalinize urine and force diuresis.
Keep container tightly close.
Store in a cool, dry place below
Protect from light Keep away from