|
 Salosone
ointment
Description
White yellowish ointment.
Content
Betamethasone dipropionate ( eq.
to betamethasone 0.05% ) ...... 0.065% w/w
Salicylic acid
..............................................................................
3.00% w/w
IndicationsIt is used for
the relief of seborrheic dermatitis, ichthyosis vulgaris, psoriasis and
other inflammatory, corticosteroid-responsive dermatoses, hyperkeratotic and
dry, scaling skin conditions.
Pharmacology
Betamethasone dipropionate is a
glucocorticoid applied topically in the management of various disorders in
which corticosteroids are indicated. It has marked antipruritic,
vasoconstrictor and anti-inflammatory activity.
Salicylic acid is a keratolytic
with bacteriostatic and fungicidal actions.
Betamethasone dipropionate is
well absorbed from the sites of local application, particularly under an
occlusive dressing or when the skin is broken. It may be absorbed to give
systemic effects. It is more slowly metabolized in the skin and this tend to
be systemically absorbed in a greater extent. Salicylic acid is also rapidly
absorbed through the skin.
Contraindications
It is contraindicated in patients
hypersensitive to salicylic acid and betamethasone dipropionate or any
related components.
Precautions
Steroids applied topically over
large areas, particularly when the skin is broken, with or without occlusive
dressings may result in systemic effects. Therefore, suitable precautions
should be taken. Special precautions have to be observed when used on
infants and children as it may cause growth retardation on prolonged use.
Therefore, avoid prolonged use in children and on the face.
It use should be discontinued if
excessive dryness, irritation or sensitization of the skin occurs.
Avoid contact with the eyes and
mucous membranes.
Use in pregnancy and lactation
Risk benefits should be
considered when using on pregnant or lactating mothers although safety of
use has not been established.
Drug Interactions
None known
Adverse effects
When applied topically,
particularly to large areas or when the skin is broken or under occlusive
dressings, betamethasone dipropionate may be absorbed in sufficient amounts
to cause systemic effects, eg. burning, itching irritation, acneiform
eruptions, hypopigmentation, perioral dermatitis, allergic contact
dermatitis, hypertrichosis and folliculitis.
Dosage and administration
Apply over affected skin twice
daily
Treatment of over dosage
Symptoms: excessive or
prolonged use of topical corticosteroids can suppress pituitary-adrenal
function, resulting in secondary adrenal insufficiency, and produce
manifestations of hypercoticism, including Cushing's disease. Prolonged use
of salicylic acid causes salicylism.
Treatment: Symptomatic
treatment is applied. Slow withdrawal of steroids in advised and treat
electrolyte imbalance, if any. For salicylism, sodium bicarbonate is given
orally to alkalinize urine and force diuresis.
Storage conditions
Keep container tightly close.
Store in a cool, dry place below
30.
Protect from light Keep away from
children
Presentation
15 gm/tube
Shelf Life
3 years |
