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Senna


Composition

Each tablet contains 7.5 mg of Sennosides.


Product description

Brown round scored tablets


Pharmaceutical form

Tablets 7.5 mg


Properties
Senna is an anthraquinone stimulant laxative which is used to treat constipation and for bowel evacuation before investigational procedures or surgery. The active anthraquinones are liberated into the colon from the sennoside glycosides by colonic bacteria and an effect usually occurs within 6 to 12 hours of administration.

 

Anthraquinone derivatives are relatively mild laxatives. Action was generally considered to result from direct stimulation of smooth muscle of the colon. More recently, change sin fluid balance and electrolyte absorption are believed to be contributing factors. Senna can alter permeability of cell walls in the colon because it increases cyclic 3',5'-adenosine monophosphate, which also regulates active ion secretion. The result is increased fluid accumulation in the colon and a laxative action.

 

Indications

In the management of constipation, including: Simple constipation, whether self-induced or environmental, e.g. neglect of the call to stool or poor sanitary conditions. Constipation in old age, especially where maintenance treatment is require. Constipation in pregnancy and the puerperium.

Idiopathic slow-transit constipation.

Constipation in the irritable bowel syndrome.

Conservative treatment of haemorrhoids.

Avoidance of straining after surgery and in cerebral and cardiovascular disease.

 

Dosage

The correct dose of Senna Tablets is the smallest required to produce a comfortable soft-formed motion. It varies between individuals, but is generally found within the following ranges :

 

Adults : 2 tablets ( up to 4 on medical advice ) at bedtime.

Children over 6 years : Half the adult dosages, taken in the morning.

 

There is no indication that dosage need be modified for the elderly.

Senna tablets are best taken as a single dose, at bedtime by adults and in the morning by children.

The tablets can be taken with a drink.

Once regularity has been achieved, dosage should be reduced and can usually be stopped.

 

Side effects

Senna Tablets are relatively free from side effects if used occasionally and for short periods of time. Long-term use or overdosage can cause abdominal pain, nausea and vomiting, loss of weight, muscle weakness, laxative dependence, hypokalaemia, or hypocalcaemia. Senna Tablets are habit-forming and can produce laxative dependence that could lead to loss of normal bowel function and constipation after therapy is discontinued. Chronic long-term use can produce cathartic colon, which resembles ulcerative colitis and is characterised by atonic colon and dilation, especially of the right side.

 

Urine discoloration can occur during Senna administration, varying from red-pink in alkaline urine to yellow-brown in acidic urine.

 

Precautions

Senna should be given with care in patients with inflammatory bowel disease. Prolonged use should be avoided.

 

Breast-feeding :

Although anthraquinone derivatives may be excreted in the milk of lactating mothers, following normal dosage the concentration is usually insufficient to affect the nursing infant.

 

Drug Interactions :

No drug interactions with Senna are known.

 

Drug/Laboratory Test Interferences :

None reported.

 

Contra-indications

Senna should not be given to patients with intestinal obstruction or with undiagnosed abdominal symptoms.

 

Senna is contraindicated for long-term use; the drug produces laxative dependency and loss of normal bowel function after therapy is discontinued. In general, laxatives should not be administered chronically.

 

Senna should not be used in patients with fluid or electrolyte imbalance; acute abdominal pain; vomiting; or appendicitis. administration can worsen these conditions.

 

Senna should be used with caution in children, and should not be sued at all in children under age 6.

 

Overdosage

In cases of accidental overdosage, where diarrhoea is severe, conservative measures are usually sufficient: generous amounts of fluid especially fruit drinks should be given.

 

Pharmaceutical Precautions

Storage conditions :

Senna Tablets should be stored below 25C, protected from light and moisture.

 

Incompatibilities :

None

 

Package

Blister packs and PP/PE containers of 1000 tablets

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