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Sinemet/Sinemet 25/100

 

Contents:

Per Sinemet tab Carbidopa 25 mg, levodopa 250 mg.

Per Sinemet 25/100tab Carbidopa 25 mg, levodopa 100 mg.

 

Indications:

Treatment of symptoms of parkinsonism.

 

Dosage:

Sinemet 25/100 1 tab three times daily. Max: 8 tab.

Sinemet 25/250 tab once-bd. Max 8 tab.

Transfer from levodopa Stop levodopa therapy 12 hourly before Sinemet is started ( 24 hours for SR preparation ).

Patients taking ≤ 1500 mg levodopa Initial: 1 tab Sinemet 25/100 three-four times daily, > 1500 mg levodopa Inital: 1 tab Sinemet three-four times daily.

 

Contraindications:

Narrow-angle glaucoma. Undiagnosed skin lesions or history of melanoma. Hypersensitivity to any component of this product.

 

Special Precautions:

Cardiovascular (CV) diseases including history of myocardial infarction (MI) or arrhythmias or pulmonary disease, bronchial asthma, renal, hepatic o endocrine disease, history of psychoses or convulsions, or wide-angle glaucoma. Absorption of I-dopa may be impaired in some patients on a high protein diet. Not recommended for children ≤ 18 years.

 

Adverse Reactions:

Dyskinesia including choreiform, dystonic & other involuntary movements. Mental changes including paranoid ideation & psychotic episodes; depression with or without development of suicidal tendencies; dementia; & gastrointestinal (GI) disturbances.

 

Drug interactions:

Discontinue MAOIs 2 weeks prior to therapy with Sinemet ( except low doses of MAO-B inhibitors ), tricyclic antidepressants, antihypertensive drugs.

 

Presentation/Packing

Tab 25/100 x 100's. 25/250 x 100's.

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