Per Sinemet tab Carbidopa 25 mg,
levodopa 250 mg.
Per Sinemet 25/100tab Carbidopa
25 mg, levodopa 100 mg.
Treatment of symptoms of
Sinemet 25/100 1 tab three
times daily. Max: 8 tab.
Sinemet 25/250 ½ tab once-bd.
Max 8 tab.
Transfer from levodopa
Stop levodopa therapy 12 hourly before Sinemet is started ( 24 hours for SR
≤ 1500 mg levodopa Initial: 1 tab Sinemet 25/100 three-four times daily, >
1500 mg levodopa Inital: 1 tab Sinemet three-four times daily.
Undiagnosed skin lesions or history of melanoma. Hypersensitivity to any
component of this product.
Cardiovascular (CV) diseases
including history of myocardial infarction (MI) or arrhythmias or pulmonary
disease, bronchial asthma, renal, hepatic o endocrine disease, history of
psychoses or convulsions, or wide-angle glaucoma. Absorption of I-dopa may
be impaired in some patients on a high protein diet. Not recommended for
≤ 18 years.
Dyskinesia including choreiform,
dystonic & other involuntary movements. Mental changes including paranoid
ideation & psychotic episodes; depression with or without development of
suicidal tendencies; dementia; & gastrointestinal (GI) disturbances.
Discontinue MAOIs 2 weeks prior
to therapy with Sinemet ( except low doses of MAO-B inhibitors ), tricyclic
antidepressants, antihypertensive drugs.
Tab 25/100 x 100's. 25/250 x