Contents:

Theophylline

Indications:

Bronchial asthma, chronic bronchitis & other conditions with bronchospasm

Dosage:

Adult

1 tab 300 mg twice daily can increase gradually after at least 3 days' treatment, or decrease by 150 mg twice daily. Alternatively, start with 200 mg twice daily & after at least 3 days' treatment can be gradually increase by 100 mg twice daily.

Children

Daily dose to be adjusted according to body weight. Once daily dosing should be considered only after the patient has been titrated to therap levels with 12 hour dosing.

Contraindications:

Acute myocardial infarction

Special precautions:

Congestive heart failure ( CHF ), liver disease, viral infection; elderly; severe hypertension; history of peptic ulcer; pregnancy & lactation; neonates; reduced thyroid function, obstructive lung disease, respiratory infection. Smoking.

Adverse Reactions:

Gastrointestinal upsets, anorexia. At high serum concentration, cramps, convulsions, supraventricular tachycardia, tachypnea; restlessness, nervousness, insomnia. Rash, dizziness, hyperglycemia.

Drug indications:

Cimetidine, ciprofloxacin, macrolide antibiotics, estrogen, allopurinol & propranolol increase plasma theophylline concentration. Phenobarb, phenytoin & rifampicin crease theophylline clearance & plasma concentration. Decreases plasma concentration of lithium.

Presentation/Packing:

Sustained action tab 200 mg x 100's, 6 x 100's.

300 mg x 100's, 6 x 100's