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 Tolnaderm cream &
lotion 1%
1. Tolnaderm Cream – White opaque cream containing 1% w/w of Tolnaftate
solubilised in a base containing Polyethylene glycol with Methyl paraben
0.16% and Propyl paraben 0.03% as preservatives.
2. Tolnaderm Lotion – Clear viscous liquid containing 1% w/v of Tolnaftate
in Polyethylene glycol.
ACTIONS:
Tolnaftate is effective in the treatment of the majority of
cutaneous mycoses caused by Trichophyton rubrum, Trichophyton
mentagrophytes, Trichophyton tonsurans, Microsporum canis,
Microsporum audouini, Microsporum gypseum, Epidermophyton
floccosum and Pityrosporum orbiculare, but is ineffective against
Candida or bacteria. Infections due to Trichophyton rubrum may
relapse and a second course of treatment may be required.
PHARMACOLOGY
Tolnaftate inhibits the growth of Epidermophyton,
Microsporum, Trichophyton spp., and Malassezia furfur, but it is not active
against Candida spp. or bacteria.
INDICATIONS
The topical
treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea
corporis (body ringworm), tines barbae (ringworm of the face and neck) and
tinea manuum due to infection with Trichophyton rubrum,
Trichophyton mentagrophytes, Trichophyton tonsurans,
Microsporum canis, Microsporum audouini, Epidermophyton
floccosum and tinea versicolor due to Pityrosporum orbiculare.
Tolnaderm Cream is indicated in tinea infections of the skin especially the
nonhairy areas of the body and including the groin. The vanishing cream base
makes it cosmetically acceptable and there is no staining of the skin or
clothing from the preparation. Tolnaderm Lotion is nonaqueous and miscible
with the exudates of fungal infections of the skin; it penetrates lesions
without destruction of the epidermis. Tolnaderm Lotion is odourless,
greaseless and does not stain or discolour the skin, hair, nails or
clothing. Tolnaftate preparations are not suitable for deep infections of
the nailbed and hair follicles but maybe applied concomitantly with a
systemic agent.
CONTRAINDICATIONS
Hypersensitivity to Tolnaftate or any component in the base.
DRUG INTERACTIONS
Not
known.
ADVERSE EFFECTS
Skin reactions to Tolnaftate including irritation
and pruritus may occur; contact dermatitis has been reported.
PRECAUTIONS/WARNINGS
If irritation or sensitivity occurs, treatment
should be discontinued. Do not use on children under 2 years of age except
under the advice and supervision of a doctor. Avoid contact with eyes and
mucous membranes (for external use only). Advise to consult doctor if no
improvement is seen in 4 weeks (for athlete's foot) or 2 weeks (for jock
itch). Not for ophthalmic use.
RECOMMENDED DOSAGE
Wash
and dry the infected area. Apply small amount of cream or lotion and spread
evenly on infected area 2 or 3 times daily for 2 to 3 weeks (or 4-6 weeks if
thickening of the skin has occurred, or the hyperkeratotic lesions can be
treated with 10% Salicylic acid ointment alternating with Tolnaderm). When
pruritus is present, it is usually relieved in 24 to 72 hours. Involution of
interdigital lesions due to susceptible fungi is very often complete in 7 to
21 days. Treatment should be continued for 2 to 3 weeks after the infection
has cleared to help prevent remission. Attention to hygiene is important in
the management of fungal infections particularly to all the folds and
creases.
PACKING
Tolnaderm Cream – Plastic jar of
450g and collapsible tube of 15g.
Tolnaderm Lotion – Plastic bottle
of 10ml.
STORAGE
Keep container well closed. Protect from strong light.
Store below 30°C. For external use only. Keep out of reach of children.
Recommended shelf-life: 3 years.
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