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Triconazole Cream

 

Composition

Triamcinolone acetonide BP ..... 0.1% w/w

Econazole nitrate BP ................ 1.0% w/w

 

Description

A white and smooth cream

 

Pharmacology

Triamcinolone acetonide and econazole nitrate combination has anti-inflammatory, anti-pruritic, anti-fungal and anti-bacterial action. When applied topically, particularly to large areas, the triamcinolone acetonide may be absorbed in sufficient amount to cause systemic effect. It is slowly metabolized in the skin and thus tend to be systemically absorbed to a greater extent.

 

After topical application to the skin of normal subjects, systemic absorption of econazole nitrate in extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes. Inhibitory concentrations are achieved in the epidermis and as deep as the middle region of the dermis. Less than 1% of the applied dose was recovered in the urine and faeces.

 

Indications

Inflammatory dermatoses with mycotic or bacterial infection. Inflammatory dermatomycoses caused by dermatophytes yeasts and molds.

 

Contraindications

It is contraindicated in patient who are hypersensitive econazole nitrate, triamcinolone or other corticosteriods.

 

Dosage

Apply cream to the affected areas twice daily.

 

Precautions

The medication should be discontinued if irritation occurred. Do not use in and around eyes. Special precaution should be taken when medication is used in children.

 

Use in Pregnancy and Lactation

Pregnant women and nursing mothers should seek the advice of the physician before using this product.

 

Side effects

The side effects consist of itching, burning, stinging, erythema, dryness, folliculitis, hypertrichosis, acne form eruption, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, seconday infection, skin atropy, striae, miliaria..

 

Symptoms and treatment for overdosage and antidote(s)

Topically applied corticosteroids can be absorbed in sufficient amount to produce systemic effect. ( See Precaution/ Warning ).

 

Pack size

A tube of 15g

Pack size ( export/tender only )

A jar of 400g

 

Shelf-life

3 years

 

Storage conditions

Store at temperature 25C. Protect from light

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