|
 Triconazole Cream
Composition
Triamcinolone acetonide BP .....
0.1% w/w
Econazole nitrate BP
................ 1.0% w/w
Description
A white and smooth cream
Pharmacology
Triamcinolone acetonide and
econazole nitrate combination has anti-inflammatory, anti-pruritic,
anti-fungal and anti-bacterial action. When applied topically, particularly
to large areas, the triamcinolone acetonide may be absorbed in sufficient
amount to cause systemic effect. It is slowly metabolized in the skin and
thus tend to be systemically absorbed to a greater extent.
After topical application to the
skin of normal subjects, systemic absorption of econazole nitrate in
extremely low. Although most of the applied drug remains on the skin
surface, drug concentrations were found in the stratum corneum which, by
far, exceeded the minimum inhibitory concentration for dermatophytes.
Inhibitory concentrations are achieved in the epidermis and as deep as the
middle region of the dermis. Less than 1% of the applied dose was recovered
in the urine and faeces.
Indications
Inflammatory dermatoses with
mycotic or bacterial infection. Inflammatory dermatomycoses caused by
dermatophytes yeasts and molds.
Contraindications
It is contraindicated in patient
who are hypersensitive econazole nitrate, triamcinolone or other
corticosteriods.
Dosage
Apply cream to the affected areas
twice daily.
Precautions
The medication should be
discontinued if irritation occurred. Do not use in and around eyes. Special
precaution should be taken when medication is used in children.
Use in Pregnancy and Lactation
Pregnant women and nursing
mothers should seek the advice of the physician before using this product.
Side effects
The side effects consist of
itching, burning, stinging, erythema, dryness, folliculitis, hypertrichosis,
acne form eruption, hypopigmentation, perioral dermatitis, allergic contact
dermatitis, maceration of the skin, seconday infection, skin atropy, striae,
miliaria..
Symptoms and treatment for
overdosage and antidote(s)
Topically applied corticosteroids
can be absorbed in sufficient amount to produce systemic effect. ( See
Precaution/ Warning ).
Pack size
A tube of 15g
Pack size ( export/tender only
)
A jar of 400g
Shelf-life
3 years
Storage conditions
Store at temperature 25°C.
Protect from light
|
