Pleasantly Flavoured Urinary Alkalinizer
Each 4g sachet contains:
Sodium bicarbonate 1.76 g
Citric acid, anhydrous 0.72
Sodium citrate, anhydrous
Tartaric acid 0.89 g
Also contains Nature Identical
Lemon Flavour oil, Terpeneless and saccharin sodium.
Each sachet contains 4g of white
effervescent granules powder to be dissolved in cold water to give clear
Sodium bicarbonate acts as
urinary alkaliser by increasing the excretion of free bicarbonate ions in
the urine, thus effectively raising the urinary pH. By maintaining an
alkaline urine, the actual dissolution of uric acid stones may be
accomplished. It also acts as antacid by chemically neutralizing or
buffering existing quantities of stomach acid but has no direct effect in
its output. This action results in increased pH value of stomach contents,
thus providing relief of hyperacidity symptoms.
Sodium Citrate and Citric Acid:
Sodium citrate is metabolized to
bicarbonates, which increases urinary pH by increasing the excretion of free
bicarbonate ions, without producing systemic alkalosis when administered in
recommended doses. A rise in urinary pH increases the solubility of cystine
in the urine and the ionization of uric acid to more soluble urate ion. By
maintaining an alkaline urine, the actual dissolution of uric acid stones
may be accomplished, It also reacts chemically to neutralize or buffer
existing quantities of gastric hydrochloric acid but has no direct effects
in its output. Sodium bicarbonate is excreted through renal and also via
lung by forming C02. Sodium citrate, citric acid and absorbed tartaric acid
are excreted through urine.
Indicated for relieving of
discomfort in mild UTI; symptomatic relief of dysuria; to enhance the action
of certain antibiotics, especially some sulphonamides; in gout therapy as
urinary alkalinisers to prevent crystallisation of urates.
Renal failure or hypernatremia;
in conjunction with hexamine mandelate or hexamine hippurate therapy because
an acidic urine is needed. Caution is advised in overt and occult cardiac
failure. Concomitant use of urinary alkalinisers and quinolone antibiotics
should be avoided; crystalluria may be more likely to occur in alkaline
Side Effects/Adverse Reactions:
The tartrate component of Ural
may be incompletely absorbed. Because of this Ural may exert a mild laxative
effect. Prolonged and excessive use may cause a systemic alkalosis and / or
This preparation contains 644mg
of sodium per sachet which should be taken into account by those on a low
Alkalinization of the urine due
to the use of Ural, theoretically, may result in a decreased therapeutic
affect of the following medications, chlorpropamide, lithium, salicylates
Alternatively, alkalinization of the urine due to the use of Ural,
theoratically, may result in an increased therapeutic effect of the
following medications, amphetamines and ephadrine / pseudoepherine.
Antacid: Concurrent use of antacids with sodium citrate and sodium
bicarbonate may promote the development of calcium stones in patients with
uric acid stones and may also cause hypernatremia.
Concurrent use at aluminium-containing entacids with salts can increase
aluminium absorption, possibly resulting in acute aluminium toxicity,
especially in patients with renal insufficiency.
Quinolones: Citrates may reduce the solubility of ciprofloxacin, norfloxacin,
or ofloxacin in the urine. Patients should be observed for signs of
crystalluria and nephrotoxicity.
Laxatives: Concurrent administration of citrates with laxatives may have an
Studies regarding the effect of
citrates on pregnancy have not been done.
Caution should be exercised when
administered to a nursing mother.
Overdosage may result in
metabolic alkalosis Ural should be discontinued, appropriate treatment
instituted and electrolyte and acid-base determinations should be carried
out as appropriate.
Dosage and Administration:
4g to 8g (1 to 2 sachets)
dissolved in cold water four times daily or as prescribed.
Effervescent granules, 12x4g or
28x4g sachets per pack.
Store at temperature below 30°C.